Effects of polydimethylsiloxane grafting on the calcification, physical properties, and biocompatibility of polyurethane in a heart valve


Journal Article

Segmented polyurethane (PU) has proven to be the best biomaterial for artificial heart valves, but the calcification of polyurethane surfaces causes serious problems in long-term implants. This work was undertaken to evaluate the effects of polydimethylsiloxane (PDMS) grafting on the calcification, biocompatibility, and blood compatibility of polyurethane. A grafted polyurethane film was compared with virgin polyurethane surfaces. Physical properties of the samples were examined using different techniques. The hydrophobicity of the polyurethane films increased as a result of silicone modification. The effects of surface modification of polyurethane films on their calcification and fibroblast cell (L 929) and platelet behavior were evaluated in vitro. Fourier transform infrared spectroscopy indicated the direct involvement of the polyether soft segments of the polymer in the calcification process. Scanning electron microscopy of films indicated that grafting of silicone rubber to the surface of polyurethane successfully prevented the calcification process. The morphology of fibroblast cells that adhered to the PU films and modified films was similar to that of controls and showed the same proliferation. On the other hand, grafting PDMS onto PU did not affect the amount of platelets that adhered to the polyurethane surfaces. © 2005 Wiley Periodicals, Inc.

Full Text

Cited Authors

  • Dabagh, M; Abdekhodaie, MJ; Khorasani, MT

Published Date

  • October 15, 2005

Published In

Volume / Issue

  • 98 / 2

Start / End Page

  • 758 - 766

International Standard Serial Number (ISSN)

  • 0021-8995

Digital Object Identifier (DOI)

  • 10.1002/app.22132

Citation Source

  • Scopus