Controlling cell–cell interactions using surface acoustic waves

Journal Article

Significance We present a unique acoustic well approach that can precisely control cell-to-cell distance and cell–cell interactions. Our technology can achieve high precision and high throughput simultaneously while preserving the integrity of cells. It is capable of creating cell assemblies with precise spatial control both in suspension and on a substrate. We envision the exploitation of this powerful technology, for example, in the study of cell–cell interactions in fields, such as immunology, developmental biology, neuroscience, and cancer metastasis, and in the studies of cell–cell and cell–matrix adhesion.

Full Text

Duke Authors

Cited Authors

  • Guo, F; Li, P; French, JB; Mao, Z; Zhao, H; Li, S; Nama, N; Fick, JR; Benkovic, SJ; Huang, TJ

Published Date

  • January 6, 2015

Published In

Volume / Issue

  • 112 / 1

Start / End Page

  • 43 - 48

Published By

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.1422068112


  • en