miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes.

Journal Article (Journal Article)

Nociception is protective and prevents tissue damage but can also facilitate chronic pain. Whether a general principle governs these two types of pain is unknown. Here, we show that both basal mechanical and neuropathic pain are controlled by the microRNA-183 (miR-183) cluster in mice. This single cluster controls more than 80% of neuropathic pain-regulated genes and scales basal mechanical sensitivity and mechanical allodynia by regulating auxiliary voltage-gated calcium channel subunits α2δ-1 and α2δ-2. Basal sensitivity is controlled in nociceptors, and allodynia involves TrkB+ light-touch mechanoreceptors. These light-touch-sensitive neurons, which normally do not elicit pain, produce pain during neuropathy that is reversed by gabapentin. Thus, a single microRNA cluster continuously scales acute noxious mechanical sensitivity in nociceptive neurons and suppresses neuropathic pain transduction in a specific, light-touch-sensitive neuronal type recruited during mechanical allodynia.

Full Text

Duke Authors

Cited Authors

  • Peng, C; Li, L; Zhang, M-D; Bengtsson Gonzales, C; Parisien, M; Belfer, I; Usoskin, D; Abdo, H; Furlan, A; Häring, M; Lallemend, F; Harkany, T; Diatchenko, L; Hökfelt, T; Hjerling-Leffler, J; Ernfors, P

Published Date

  • June 16, 2017

Published In

Volume / Issue

  • 356 / 6343

Start / End Page

  • 1168 - 1171

PubMed ID

  • 28572455

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.aam7671

Language

  • eng

Conference Location

  • United States