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Progressive Retinal Vasodilation in Patients With Type 1 Diabetes: A Longitudinal Study of Retinal Vascular Geometry.

Publication ,  Journal Article
Liew, G; Benitez-Aguirre, P; Craig, ME; Jenkins, AJ; Hodgson, LAB; Kifley, A; Mitchell, P; Wong, TY; Donaghue, K
Published in: Invest Ophthalmol Vis Sci
May 1, 2017

PURPOSE: Retinal vessels can be used to noninvasively monitor changes in microvasculature. These changes in retinal vascular geometry (RVG) may predict chronic diabetes complications. We evaluated longitudinal RVG changes in adolescents with type 1 diabetes. METHODS: We followed 102 adolescents (baseline: 47.1% male, mean [SD] age 14.4 [1.6] years, diabetes duration 7.2 [3.1] years, HbA1c 8.1% [1.3%] [65 (9.3) mmol/mol]) over three visits, with a mean follow-up of 2.6 years. Retinal vascular geometry was measured using a standardized computer-assisted protocol from retinal photographs at each visit. Multivariable linear mixed-models and logistic regression were used to examine predictors of RVG and diabetic retinopathy. RESULTS: During follow-up, mean arteriolar caliber, venular caliber, and venular tortuosity increased, from 156.0 (SD, 14.5) to 164.9 (14.0) μm, 215.9 (22.5) to 230.3 (20.6) μm, and 1.096 (0.014) to 1.099 (0.016), respectively (all P < 0.005). Other RVG measurements (fractal dimension, branching angle, length to diameter ratio) remained stable. Higher than baseline HbA1c and longer diabetes duration were associated with greater venular vasodilation. Retinopathy developed at any time-point in 24% of subjects, and the highest tertile arteriolar fractal dimension was associated with cumulative incidence of retinopathy (multivariable odds ratio 3.2, 95% confidence interval 1.0-9.6; P = 0.04). CONCLUSIONS: Higher HbA1c and longer diabetes duration in early adolescence predicts greater venular vasodilation over time. Arteriolar fractal dimension predicts subsequent retinopathy development, suggesting value as a potential biomarker for diabetic complications.

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

May 1, 2017

Volume

58

Issue

5

Start / End Page

2503 / 2509

Location

United States

Related Subject Headings

  • Young Adult
  • Vasodilation
  • Time Factors
  • Risk Factors
  • Retinal Vessels
  • Prospective Studies
  • Prognosis
  • Ophthalmology & Optometry
  • Microvessels
  • Male
 

Citation

APA
Chicago
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MLA
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Liew, G., Benitez-Aguirre, P., Craig, M. E., Jenkins, A. J., Hodgson, L. A. B., Kifley, A., … Donaghue, K. (2017). Progressive Retinal Vasodilation in Patients With Type 1 Diabetes: A Longitudinal Study of Retinal Vascular Geometry. Invest Ophthalmol Vis Sci, 58(5), 2503–2509. https://doi.org/10.1167/iovs.16-21015
Liew, Gerald, Paul Benitez-Aguirre, Maria E. Craig, Alicia J. Jenkins, Lauren A. B. Hodgson, Annette Kifley, Paul Mitchell, Tien Y. Wong, and Kim Donaghue. “Progressive Retinal Vasodilation in Patients With Type 1 Diabetes: A Longitudinal Study of Retinal Vascular Geometry.Invest Ophthalmol Vis Sci 58, no. 5 (May 1, 2017): 2503–9. https://doi.org/10.1167/iovs.16-21015.
Liew G, Benitez-Aguirre P, Craig ME, Jenkins AJ, Hodgson LAB, Kifley A, et al. Progressive Retinal Vasodilation in Patients With Type 1 Diabetes: A Longitudinal Study of Retinal Vascular Geometry. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2503–9.
Liew, Gerald, et al. “Progressive Retinal Vasodilation in Patients With Type 1 Diabetes: A Longitudinal Study of Retinal Vascular Geometry.Invest Ophthalmol Vis Sci, vol. 58, no. 5, May 2017, pp. 2503–09. Pubmed, doi:10.1167/iovs.16-21015.
Liew G, Benitez-Aguirre P, Craig ME, Jenkins AJ, Hodgson LAB, Kifley A, Mitchell P, Wong TY, Donaghue K. Progressive Retinal Vasodilation in Patients With Type 1 Diabetes: A Longitudinal Study of Retinal Vascular Geometry. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2503–2509.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

May 1, 2017

Volume

58

Issue

5

Start / End Page

2503 / 2509

Location

United States

Related Subject Headings

  • Young Adult
  • Vasodilation
  • Time Factors
  • Risk Factors
  • Retinal Vessels
  • Prospective Studies
  • Prognosis
  • Ophthalmology & Optometry
  • Microvessels
  • Male