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Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.

Publication ,  Journal Article
Wu, Y; Marvelle, AF; Li, J; Croteau-Chonka, DC; Feranil, AB; Kuzawa, CW; Li, Y; Adair, LS; Mohlke, KL
Published in: J Lipid Res
November 2013

Blood levels of lipoprotein cholesterol and triglycerides (TGs) are highly heritable and are major risk factors for cardiovascular disease (CVD). Approximately 100 lipid-associated loci have been identified in populations of European ancestry. We performed a genome-wide association study of lipid traits in 1,782 Filipino women from the Cebu Longitudinal Health and Nutrition Survey, and tested for evidence of interactions with waist circumference. We conducted additional association and interaction analyses in 1,719 of their young adult offspring. Genome-wide significant associations (P < 5 × 10⁻⁸) were detected at APOE for low density lipoprotein cholesterol and total cholesterol, and at APOA5 for TGs. Suggestive associations (P < 10⁻⁶) were detected at GCKR for TGs, and at CETP and TOM1 for high density lipoprotein cholesterol. Our data also supported the existence of allelic heterogeneity at APOA5, CETP, LIPC, and APOE. The secondary signal (Gly185Cys) at APOA5 exhibited a single nucleotide polymorphism (SNP)-by-waist circumference interaction affecting TGs (Pinteraction = 1.6 × 10⁻⁴), manifested by stronger SNP effects as waist circumference increased. These findings provide the first evidence that central obesity may accentuate the effect of the TG-increasing allele of the APOA5 signal, emphasizing that CVD risk could be reduced by central obesity control.

Duke Scholars

Published In

J Lipid Res

DOI

EISSN

1539-7262

Publication Date

November 2013

Volume

54

Issue

11

Start / End Page

3198 / 3205

Location

United States

Related Subject Headings

  • Waist Circumference
  • Triglycerides
  • Pregnancy
  • Polymorphism, Single Nucleotide
  • Philippines
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genome-Wide Association Study
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wu, Y., Marvelle, A. F., Li, J., Croteau-Chonka, D. C., Feranil, A. B., Kuzawa, C. W., … Mohlke, K. L. (2013). Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels. J Lipid Res, 54(11), 3198–3205. https://doi.org/10.1194/jlr.P042077
Wu, Ying, Amanda F. Marvelle, Jin Li, Damien C. Croteau-Chonka, Alan B. Feranil, Christopher W. Kuzawa, Yun Li, Linda S. Adair, and Karen L. Mohlke. “Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.J Lipid Res 54, no. 11 (November 2013): 3198–3205. https://doi.org/10.1194/jlr.P042077.
Wu Y, Marvelle AF, Li J, Croteau-Chonka DC, Feranil AB, Kuzawa CW, et al. Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels. J Lipid Res. 2013 Nov;54(11):3198–205.
Wu, Ying, et al. “Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.J Lipid Res, vol. 54, no. 11, Nov. 2013, pp. 3198–205. Pubmed, doi:10.1194/jlr.P042077.
Wu Y, Marvelle AF, Li J, Croteau-Chonka DC, Feranil AB, Kuzawa CW, Li Y, Adair LS, Mohlke KL. Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels. J Lipid Res. 2013 Nov;54(11):3198–3205.

Published In

J Lipid Res

DOI

EISSN

1539-7262

Publication Date

November 2013

Volume

54

Issue

11

Start / End Page

3198 / 3205

Location

United States

Related Subject Headings

  • Waist Circumference
  • Triglycerides
  • Pregnancy
  • Polymorphism, Single Nucleotide
  • Philippines
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genome-Wide Association Study