Molecular mechanisms of astrocyte-induced synaptogenesis.

Journal Article (Journal Article;Review)

Astrocytes are morphologically complex cells that perform a wide variety of critical functions in the brain. As a structurally and functionally integrated component of the synapse, astrocytes secrete proteins, lipids, and small molecules that bind neuronal receptors to promote synaptogenesis and regulate synaptic connectivity. Additionally, astrocytes are key players in circuit formation, instructing the formation of synapses between distinct classes of neurons. This review highlights recent publications on the topic of astrocyte-mediated synaptogenesis, with a focus on the molecular mechanisms through which astrocytes orchestrate the formation of synaptic circuits.

Full Text

Duke Authors

Cited Authors

  • Baldwin, KT; Eroglu, C

Published Date

  • August 2017

Published In

Volume / Issue

  • 45 /

Start / End Page

  • 113 - 120

PubMed ID

  • 28570864

Pubmed Central ID

  • PMC5573249

Electronic International Standard Serial Number (EISSN)

  • 1873-6882

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2017.05.006

Language

  • eng

Conference Location

  • England