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Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury.

Publication ,  Journal Article
Chaikittisilpa, N; Krishnamoorthy, V; Lele, AV; Qiu, Q; Vavilala, MS
Published in: J Neurosci Res
April 2018

Systolic dysfunction was recently described following traumatic brain injury (TBI), and systemic inflammation may be a contributing mechanism. Our aims were to 1) examine the association between the early systemic inflammatory response syndrome (SIRS) and systolic cardiac dysfunction following TBI, and 2) describe the longitudinal change in SIRS criteria, cardiac function, and hemodynamic parameters during the first week of hospitalization. We used a secondary analysis of a prospective cohort study examining cardiac function (with transthoracic echocardiography on the first day and serially over the first week of hospitalization) in 32 moderate-severe isolated TBI patients, and quantified the admission and daily SIRS response to injury. We determined the association of admission SIRS and systolic dysfunction following TBI. Admission SIRS was present in 7 (21%) patients and was associated with systolic dysfunction on multivariable analysis (relative risk 4.01; 95% 1.16-13.79, p = .028). Both SIRS criteria and systolic cardiac function improved over the first week of hospitalization. In conclusion, early SIRS is common among patients with moderate-severe TBI, and the presence of SIRS criteria on admission is associated with systolic cardiac dysfunction following TBI.

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Published In

J Neurosci Res

DOI

EISSN

1097-4547

Publication Date

April 2018

Volume

96

Issue

4

Start / End Page

661 / 670

Location

United States

Related Subject Headings

  • Systemic Inflammatory Response Syndrome
  • Risk Factors
  • Prospective Studies
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Heart Diseases
  • Glasgow Coma Scale
  • Female
 

Citation

APA
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ICMJE
MLA
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Chaikittisilpa, N., Krishnamoorthy, V., Lele, A. V., Qiu, Q., & Vavilala, M. S. (2018). Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury. J Neurosci Res, 96(4), 661–670. https://doi.org/10.1002/jnr.24100
Chaikittisilpa, Nophanan, Vijay Krishnamoorthy, Abhijit V. Lele, Qian Qiu, and Monica S. Vavilala. “Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury.J Neurosci Res 96, no. 4 (April 2018): 661–70. https://doi.org/10.1002/jnr.24100.
Chaikittisilpa N, Krishnamoorthy V, Lele AV, Qiu Q, Vavilala MS. Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury. J Neurosci Res. 2018 Apr;96(4):661–70.
Chaikittisilpa, Nophanan, et al. “Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury.J Neurosci Res, vol. 96, no. 4, Apr. 2018, pp. 661–70. Pubmed, doi:10.1002/jnr.24100.
Chaikittisilpa N, Krishnamoorthy V, Lele AV, Qiu Q, Vavilala MS. Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury. J Neurosci Res. 2018 Apr;96(4):661–670.
Journal cover image

Published In

J Neurosci Res

DOI

EISSN

1097-4547

Publication Date

April 2018

Volume

96

Issue

4

Start / End Page

661 / 670

Location

United States

Related Subject Headings

  • Systemic Inflammatory Response Syndrome
  • Risk Factors
  • Prospective Studies
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Heart Diseases
  • Glasgow Coma Scale
  • Female