Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury.

Journal Article (Journal Article)

Systolic dysfunction was recently described following traumatic brain injury (TBI), and systemic inflammation may be a contributing mechanism. Our aims were to 1) examine the association between the early systemic inflammatory response syndrome (SIRS) and systolic cardiac dysfunction following TBI, and 2) describe the longitudinal change in SIRS criteria, cardiac function, and hemodynamic parameters during the first week of hospitalization. We used a secondary analysis of a prospective cohort study examining cardiac function (with transthoracic echocardiography on the first day and serially over the first week of hospitalization) in 32 moderate-severe isolated TBI patients, and quantified the admission and daily SIRS response to injury. We determined the association of admission SIRS and systolic dysfunction following TBI. Admission SIRS was present in 7 (21%) patients and was associated with systolic dysfunction on multivariable analysis (relative risk 4.01; 95% 1.16-13.79, p = .028). Both SIRS criteria and systolic cardiac function improved over the first week of hospitalization. In conclusion, early SIRS is common among patients with moderate-severe TBI, and the presence of SIRS criteria on admission is associated with systolic cardiac dysfunction following TBI.

Full Text

Duke Authors

Cited Authors

  • Chaikittisilpa, N; Krishnamoorthy, V; Lele, AV; Qiu, Q; Vavilala, MS

Published Date

  • April 2018

Published In

Volume / Issue

  • 96 / 4

Start / End Page

  • 661 - 670

PubMed ID

  • 28573763

Pubmed Central ID

  • PMC5712282

Electronic International Standard Serial Number (EISSN)

  • 1097-4547

Digital Object Identifier (DOI)

  • 10.1002/jnr.24100


  • eng

Conference Location

  • United States