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Origin of Barrett's Epithelium: Esophageal Submucosal Glands.

Publication ,  Journal Article
Garman, KS
Published in: Cell Mol Gastroenterol Hepatol
July 2017

The origin of the progenitor cell for Barrett's esophagus remains a major unsolved mystery. Understanding the source of this progenitor may improve strategies to prevent the development of esophageal adenocarcinoma. Esophageal submucosal glands (ESMGs) and ducts may serve as a potential source of progenitor cells that respond to esophageal injury. Through the use of human histologic and molecular analysis, ESMGs and ducts have been described in physical continuity with areas of columnar esophagus, and shared mutations have been described between ESMG ducts and Barrett's esophagus. Acinar ductal metaplasia, associated with carcinogenesis in other organs, occurs within ESMGs with human esophageal injury and esophageal adenocarcinoma. By using atypical animal models, a squamous epithelial defect well above the gastroesophageal junction healed to columnar epithelium and continuity of ESMG ducts was noted in the new epithelium. Increased proliferation in ESMGs and ducts in response to injury also has been noted in human beings and animals.

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Published In

Cell Mol Gastroenterol Hepatol

DOI

ISSN

2352-345X

Publication Date

July 2017

Volume

4

Issue

1

Start / End Page

153 / 156

Location

United States

Related Subject Headings

  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology
 

Citation

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Garman, K. S. (2017). Origin of Barrett's Epithelium: Esophageal Submucosal Glands. Cell Mol Gastroenterol Hepatol, 4(1), 153–156. https://doi.org/10.1016/j.jcmgh.2017.01.016
Garman, Katherine S. “Origin of Barrett's Epithelium: Esophageal Submucosal Glands.Cell Mol Gastroenterol Hepatol 4, no. 1 (July 2017): 153–56. https://doi.org/10.1016/j.jcmgh.2017.01.016.
Garman KS. Origin of Barrett's Epithelium: Esophageal Submucosal Glands. Cell Mol Gastroenterol Hepatol. 2017 Jul;4(1):153–6.
Garman, Katherine S. “Origin of Barrett's Epithelium: Esophageal Submucosal Glands.Cell Mol Gastroenterol Hepatol, vol. 4, no. 1, July 2017, pp. 153–56. Pubmed, doi:10.1016/j.jcmgh.2017.01.016.
Garman KS. Origin of Barrett's Epithelium: Esophageal Submucosal Glands. Cell Mol Gastroenterol Hepatol. 2017 Jul;4(1):153–156.
Journal cover image

Published In

Cell Mol Gastroenterol Hepatol

DOI

ISSN

2352-345X

Publication Date

July 2017

Volume

4

Issue

1

Start / End Page

153 / 156

Location

United States

Related Subject Headings

  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology