Genetic Analysis of Complex Traits in Saccharomyces cerevisiae.

Published

Journal Article

Defining the relationship between genotype and phenotype is a central challenge in biology. A powerful approach to this problem is to determine the genetic architecture and molecular basis of phenotypic differences among genetically diverse individuals. Saccharomyces cerevisiae is an important model system for such work. Current genetic mapping approaches for this species exploit high-throughput phenotyping and sequencing to facilitate the detection of a large fraction of the genomic loci that underlie trait variation among isolates. Once identified, several methods exist to determine the specific genes and genetic variants that underlie these loci and cause phenotypic variations. In this introduction, we provide a brief overview of research on complex traits in yeast and discuss different genetic mapping approaches applied to yeast studies.

Full Text

Duke Authors

Cited Authors

  • Ehrenreich, IM; Magwene, PM

Published Date

  • June 2017

Published In

Volume / Issue

  • 2017 / 6

Start / End Page

  • pdb.top077602 -

PubMed ID

  • 28572210

Pubmed Central ID

  • 28572210

Electronic International Standard Serial Number (EISSN)

  • 1559-6095

International Standard Serial Number (ISSN)

  • 1940-3402

Digital Object Identifier (DOI)

  • 10.1101/pdb.top077602

Language

  • eng