Cardiac regeneration strategies: Staying young at heart.


Journal Article (Review)

The human heart is continually operating as a muscular pump, contracting, on average, 80 times per minute to propel 8000 liters of blood through body tissues each day. Whereas damaged skeletal muscle has a profound capacity to regenerate, heart muscle, at least in mammals, has poor regenerative potential. This deficiency is attributable to the lack of resident cardiac stem cells, combined with roadblocks that limit adult cardiomyocytes from entering the cell cycle and completing division. Insights for regeneration have recently emerged from studies of animals with an elevated innate capacity for regeneration, the innovation of stem cell and reprogramming technologies, and a clearer understanding of the cardiomyocyte genetic program and key extrinsic signals. Methods to augment heart regeneration now have potential to counteract the high morbidity and mortality of cardiovascular disease.

Full Text

Duke Authors

Cited Authors

  • Tzahor, E; Poss, KD

Published Date

  • June 9, 2017

Published In

Volume / Issue

  • 356 / 6342

Start / End Page

  • 1035 - 1039

PubMed ID

  • 28596337

Pubmed Central ID

  • 28596337

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.aam5894


  • eng

Conference Location

  • United States