MP11: COMORBID DEPRESSION OR ANXIETY IS ASSOCIATED WITH AORTIC VASCULAR INFLAMMATION AND CORONARY HEART DISEASE BEYOND TRADITIONAL CARDIOVASCULAR RISK FACTORS IN PSORIASIS

Published

Conference Paper

Purpose of StudyPsoriasis is a chronic inflammatory disorder associated with vascular inflammation (VI), measured by 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT), and increased risk of MI. Patients with psoriasis are more likely to have comorbid depression and anxiety. Whether these comorbidities accelerate the development of CVD in psoriasis is unclear. We hypothesized that aortic VI and coronary plaque burden would be increased in patients with psoriasis who have depression and/or anxiety compared to those with psoriasis who do not.Methods UsedPatients were prospectively enrolled. Those who reported a history of depression and/or anxiety (n=40) on survey and age- and gender-matched patients who reported no history of psychiatric illness (n=40) were selected. Target-to-Background ratio from 18FDG PET/CT was used to assess aortic VI, and coronary CT angiography scans were analyzed for coronary plaque composition.Summary of ResultsBoth aortic VI and coronary plaque burden were higher in psoriasis patients with comorbid depression or anxiety compared to those without (table 1). After adjustment for Framingham Risk Score, body mass index, and statin use; VI (β=0.24, p=0.02), total plaque burden (β=0.13, p=0.04), and non-calcified burden (β=0.13, p=0.04) were associated with comorbid depression and/or anxiety.ConclusionsPatients with psoriasis who have comorbid depression or anxiety have increased aortic VI and coronary plaque burden, suggesting that identification of psychiatric diagnoses in psoriasis may be warranted for future CV risk reduction in this high risk population.Abstract MP11 Figure 1

Full Text

Duke Authors

Cited Authors

  • Aberra, T; Joshi, A; Lerman, J; Rodante, J; Silverman, J; Aridi, T; Chen, M; Playford, M; Mehta, N

Published Date

  • March 2016

Published In

Volume / Issue

  • 64 / 3

Start / End Page

  • 809.1 - 809

Published By

Electronic International Standard Serial Number (EISSN)

  • 1708-8267

International Standard Serial Number (ISSN)

  • 1081-5589

Digital Object Identifier (DOI)

  • 10.1136/jim-2016-000080.23