Myeloid Cells in the Central Nervous System.

Journal Article (Journal Article;Review)

The central nervous system (CNS) and its meningeal coverings accommodate a diverse myeloid compartment that includes parenchymal microglia and perivascular macrophages, as well as choroid plexus and meningeal macrophages, dendritic cells, and granulocytes. These myeloid populations enjoy an intimate relationship with the CNS, where they play an essential role in both health and disease. Although the importance of these cells is clearly recognized, their exact function in the CNS continues to be explored. Here, we review the subsets of myeloid cells that inhabit the parenchyma, meninges, and choroid plexus and discuss their roles in CNS homeostasis. We also discuss the role of these cells in various neurological pathologies, such as autoimmunity, mechanical injury, neurodegeneration, and infection. We highlight the neuroprotective nature of certain myeloid cells by emphasizing their therapeutic potential for the treatment of neurological conditions.

Full Text

Duke Authors

Cited Authors

  • Herz, J; Filiano, AJ; Smith, A; Yogev, N; Kipnis, J

Published Date

  • June 20, 2017

Published In

Volume / Issue

  • 46 / 6

Start / End Page

  • 943 - 956

PubMed ID

  • 28636961

Pubmed Central ID

  • PMC5657250

Electronic International Standard Serial Number (EISSN)

  • 1097-4180

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2017.06.007


  • eng

Conference Location

  • United States