Engineering challenges for brain tumor immunotherapy.

Journal Article (Review;Journal Article)

Malignant brain tumors represent one of the most devastating forms of cancer with abject survival rates that have not changed in the past 60years. This is partly because the brain is a critical organ, and poses unique anatomical, physiological, and immunological barriers. The unique interplay of these barriers also provides an opportunity for creative engineering solutions. Cancer immunotherapy, a means of harnessing the host immune system for anti-tumor efficacy, is becoming a standard approach for treating many cancers. However, its use in brain tumors is not widespread. This review discusses the current approaches, and hurdles to these approaches in treating brain tumors, with a focus on immunotherapies. We identify critical barriers to immunoengineering brain tumor therapies and discuss possible solutions to these challenges.

Full Text

Duke Authors

Cited Authors

  • Lyon, JG; Mokarram, N; Saxena, T; Carroll, SL; Bellamkonda, RV

Published Date

  • May 2017

Published In

Volume / Issue

  • 114 /

Start / End Page

  • 19 - 32

PubMed ID

  • 28625831

Pubmed Central ID

  • 28625831

Electronic International Standard Serial Number (EISSN)

  • 1872-8294

International Standard Serial Number (ISSN)

  • 0169-409X

Digital Object Identifier (DOI)

  • 10.1016/j.addr.2017.06.006


  • eng