Coming full circle in the measurement of medication adherence: opportunities and implications for health care.

Published online

Journal Article

There is little debate that medication nonadherence is a major public health issue and that measuring nonadherence is a crucial step toward improving it. Moreover, while measuring adherence is becoming both more feasible and more common in the era of electronic information, the reliability and usefulness of various measurements of adherence have not been well established. This paper outlines the most commonly used measures of adherence and discusses the advantages and disadvantages of each that depend on the purpose for which the measure will be used. International consensus statements on definitions and guidelines for selection and use of medication adherence measures were reviewed. The quality of recommended measures was evaluated in selected publications from 2009 to 2014. The most robust medication adherence measures are often ill suited for large-scale use. Less robust measures were found to be commonly misapplied and subsequently misinterpreted in population-level analyses. Adherence assessment and measurement were rarely integrated into standard patient care practice patterns. Successful scalable and impactful strategies to improve medication adherence will depend on understanding how to efficiently and effectively measure adherence.

Full Text

Duke Authors

Cited Authors

  • Whalley Buono, E; Vrijens, B; Bosworth, HB; Liu, LZ; Zullig, LL; Granger, BB

Published Date

  • 2017

Published In

Volume / Issue

  • 11 /

Start / End Page

  • 1009 - 1017

PubMed ID

  • 28652710

Pubmed Central ID

  • 28652710

International Standard Serial Number (ISSN)

  • 1177-889X

Digital Object Identifier (DOI)

  • 10.2147/PPA.S127131


  • eng

Conference Location

  • New Zealand