Arterial waveguide model for shear wave elastography: implementation and in vitro validation.

Journal Article

Arterial stiffness is found to be an early indicator of many cardiovascular diseases. Among various techniques, shear wave elastography has emerged as a promising tool for estimating local arterial stiffness through the observed dispersion of guided waves. In this paper, we develop efficient models for the computational simulation of guided wave dispersion in arterial walls. The models are capable of considering fluid-loaded tubes, immersed in fluid or embedded in a solid, which are encountered in in vitro/ex vivo, and in vivo experiments. The proposed methods are based on judiciously combining Fourier transformation and finite element discretization, leading to a significant reduction in computational cost while fully capturing complex 3D wave propagation. The developed methods are implemented in open-source code, and verified by comparing them with significantly more expensive, fully 3D finite element models. We also validate the models using the shear wave elastography of tissue-mimicking phantoms. The computational efficiency of the developed methods indicates the possibility of being able to estimate arterial stiffness in real time, which would be beneficial in clinical settings.

Full Text

Duke Authors

Cited Authors

  • Astaneh, AV; Urban, MW; Aquino, W; Greenleaf, JF; Guddati, MN

Published Date

  • July 2017

Published In

Volume / Issue

  • 62 / 13

Start / End Page

  • 5473 - 5494

PubMed ID

  • 28609299

Electronic International Standard Serial Number (EISSN)

  • 1361-6560

International Standard Serial Number (ISSN)

  • 0031-9155

Digital Object Identifier (DOI)

  • 10.1088/1361-6560/aa6ee3

Language

  • eng