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Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants.

Publication ,  Journal Article
Lee, JH; Greenberg, RG; Quek, BH; Clark, RH; Laughon, MM; Smith, PB; Hornik, CP
Published in: Cardiol Young
November 2017

BACKGROUND: In very low birth weight infants, persistence of a patent ductus arteriosus results in morbidity and mortality. Therapies to close the ductus are effective, but clinical outcomes may depend on the accuracy of diagnosis and the timing of administration. The objective of the present study was to characterise the association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants. METHODS: This retrospective cohort study used electronic health record data on inborn infants of gestational age ⩽28 weeks and birth weight <1500 g who were discharged after day of life 7 from 362 neonatal ICU from 1997 to 2013. The primary outcome was death between day of life 7 and discharge. Secondary outcomes included bronchopulmonary dysplasia, necrotising enterocolitis, and grade 3 or 4 intraventricular haemorrhage. RESULTS: This study included a total of 48,551 infants with a median gestational age of 27 weeks (interquartile range 25, 28) and birth weight 870 g (706, 1050). Early echocardiography - that is, performed during days of life 2 to 6 - was performed in 15,971/48,551 (33%) infants, and patent ductus arteriosus was diagnosed in 31,712/48,551 (65%). The diagnosis was more common in infants who had undergone early echocardiography (14,549/15,971 [91%] versus 17,163/32,580 [53%], p<0.001). In multivariable analysis, early echocardiography was not associated with reduced mortality (odds ratio 0.97, 95% CI 0.89-1.05). Results were similar in the subset of infants who received therapy for patent ductus arteriosus (odds ratio 1.01, 95% CI 0.90-1.15). CONCLUSIONS: Early echocardiography was associated with an increased diagnosis of patent ductus arteriosus, but not with decreased mortality.

Duke Scholars

Published In

Cardiol Young

DOI

EISSN

1467-1107

Publication Date

November 2017

Volume

27

Issue

9

Start / End Page

1732 / 1739

Location

England

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Male
  • Logistic Models
  • Intensive Care Units, Neonatal
  • Infant, Very Low Birth Weight
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
 

Citation

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ICMJE
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Lee, J. H., Greenberg, R. G., Quek, B. H., Clark, R. H., Laughon, M. M., Smith, P. B., & Hornik, C. P. (2017). Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants. Cardiol Young, 27(9), 1732–1739. https://doi.org/10.1017/S1047951117001081
Lee, Jan Hau, Rachel G. Greenberg, Bin H. Quek, Reese H. Clark, Matthew M. Laughon, P Brian Smith, and Christoph P. Hornik. “Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants.Cardiol Young 27, no. 9 (November 2017): 1732–39. https://doi.org/10.1017/S1047951117001081.
Lee JH, Greenberg RG, Quek BH, Clark RH, Laughon MM, Smith PB, et al. Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants. Cardiol Young. 2017 Nov;27(9):1732–9.
Lee, Jan Hau, et al. “Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants.Cardiol Young, vol. 27, no. 9, Nov. 2017, pp. 1732–39. Pubmed, doi:10.1017/S1047951117001081.
Lee JH, Greenberg RG, Quek BH, Clark RH, Laughon MM, Smith PB, Hornik CP. Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants. Cardiol Young. 2017 Nov;27(9):1732–1739.
Journal cover image

Published In

Cardiol Young

DOI

EISSN

1467-1107

Publication Date

November 2017

Volume

27

Issue

9

Start / End Page

1732 / 1739

Location

England

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Male
  • Logistic Models
  • Intensive Care Units, Neonatal
  • Infant, Very Low Birth Weight
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans