Using stroboscopic flow imaging to validate large-scale computational fluid dynamics simulations

Conference Paper

Copyright © 2017 SPIE. The utility and accuracy of computational modeling often requires direct validation against experimental measurements. The work presented here is motivated by taking a combined experimental and computational approach to determine the ability of large-scale computational fluid dynamics (CFD) simulations to understand and predict the dynamics of circulating tumor cells in clinically relevant environments. We use stroboscopic light sheet fluorescence imaging to track the paths and measure the velocities of fluorescent microspheres throughout a human aorta model. Performed over complex physiologicallyrealistic 3D geometries, large data sets are acquired with microscopic resolution over macroscopic distances.

Full Text

Duke Authors

Cited Authors

  • Laurence, TA; Ly, S; Fong, E; Shusteff, M; Randles, A; Gounley, J; Draeger, E

Published Date

  • January 1, 2017

Published In

Volume / Issue

  • 10076 /

International Standard Serial Number (ISSN)

  • 1605-7422

International Standard Book Number 13 (ISBN-13)

  • 9781510605930

Digital Object Identifier (DOI)

  • 10.1117/12.2253319

Citation Source

  • Scopus