Dual-axis optical coherence tomography for deep tissue imaging.

Journal Article (Journal Article)

We have developed dual-axis optical coherence tomography (DA-OCT) which enables deep tissue imaging by using a novel off-axis illumination/detection configuration. DA-OCT offers a 100-fold speed increase compared with its predecessor, multispectral multiple-scattering low coherence interferometry (ms2/LCI), by using a new beam scanning mechanism based on a microelectro-mechanical system (MEMS) mirror. The data acquisition scheme was altered to take advantage of this scanning speed, producing tomographic images at a rate of 4 frames (B-scans) per second. DA-OCT differs from ms2/LCI in that the dual axes intersect at a shallower depth (∼1  mm). This difference, coupled with the faster scanning speed, shifts the detection priority from multiply scattered to ballistic light. The utility of this approach was demonstrated by imaging both ex vivo porcine ear skin and in vivo rat skin from a McFarlane flap model. The enhanced penetration depth provided by the DA-OCT system will be beneficial to various clinical applications in dermatology and surgery.

Full Text

Duke Authors

Cited Authors

  • Zhao, Y; Eldridge, WJ; Maher, JR; Kim, S; Crose, M; Ibrahim, M; Levinson, H; Wax, A

Published Date

  • June 15, 2017

Published In

Volume / Issue

  • 42 / 12

Start / End Page

  • 2302 - 2305

PubMed ID

  • 28614337

Pubmed Central ID

  • PMC5639437

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

Digital Object Identifier (DOI)

  • 10.1364/OL.42.002302


  • eng

Conference Location

  • United States