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rqt: an R package for gene-level meta-analysis.

Publication ,  Journal Article
Zhbannikov, IY; Arbeev, KG; Yashin, AI
Published in: Bioinformatics (Oxford, England)
October 2017

Despite recent advances of modern GWAS methods, it is still remains an important problem of addressing calculation an effect size and corresponding p-value for the whole gene rather than for single variant.We developed an R package rqt, which offers gene-level GWAS meta-analysis. The package can be easily included into bioinformatics pipeline or used stand-alone. We applied this tool to the analysis of Alzheimer's disease data from three datasets CHS, FHS and LOADFS. Test results from meta-analysis of three Alzheimer studies show its applicability for association testing.The package rqt is freely available under the following link: https://github.com/izhbannikov/rqt.ilya.zhbannikov@duke.edu.Supplementary data are available at Bioinformatics online.

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Published In

Bioinformatics (Oxford, England)

DOI

EISSN

1367-4811

ISSN

1367-4803

Publication Date

October 2017

Volume

33

Issue

19

Start / End Page

3129 / 3130

Related Subject Headings

  • Software
  • Meta-Analysis as Topic
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation
  • Genes
  • Bioinformatics
  • Alzheimer Disease
  • 49 Mathematical sciences
  • 46 Information and computing sciences
 

Citation

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Zhbannikov, I. Y., Arbeev, K. G., & Yashin, A. I. (2017). rqt: an R package for gene-level meta-analysis. Bioinformatics (Oxford, England), 33(19), 3129–3130. https://doi.org/10.1093/bioinformatics/btx395
Zhbannikov, Ilya Y., Konstantin G. Arbeev, and Anatoliy I. Yashin. “rqt: an R package for gene-level meta-analysis.Bioinformatics (Oxford, England) 33, no. 19 (October 2017): 3129–30. https://doi.org/10.1093/bioinformatics/btx395.
Zhbannikov IY, Arbeev KG, Yashin AI. rqt: an R package for gene-level meta-analysis. Bioinformatics (Oxford, England). 2017 Oct;33(19):3129–30.
Zhbannikov, Ilya Y., et al. “rqt: an R package for gene-level meta-analysis.Bioinformatics (Oxford, England), vol. 33, no. 19, Oct. 2017, pp. 3129–30. Epmc, doi:10.1093/bioinformatics/btx395.
Zhbannikov IY, Arbeev KG, Yashin AI. rqt: an R package for gene-level meta-analysis. Bioinformatics (Oxford, England). 2017 Oct;33(19):3129–3130.

Published In

Bioinformatics (Oxford, England)

DOI

EISSN

1367-4811

ISSN

1367-4803

Publication Date

October 2017

Volume

33

Issue

19

Start / End Page

3129 / 3130

Related Subject Headings

  • Software
  • Meta-Analysis as Topic
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation
  • Genes
  • Bioinformatics
  • Alzheimer Disease
  • 49 Mathematical sciences
  • 46 Information and computing sciences