rqt: an R package for gene-level meta-analysis.
Journal Article (Journal Article)
Motivation
Despite recent advances of modern GWAS methods, it is still remains an important problem of addressing calculation an effect size and corresponding p-value for the whole gene rather than for single variant.Results
We developed an R package rqt, which offers gene-level GWAS meta-analysis. The package can be easily included into bioinformatics pipeline or used stand-alone. We applied this tool to the analysis of Alzheimer's disease data from three datasets CHS, FHS and LOADFS. Test results from meta-analysis of three Alzheimer studies show its applicability for association testing.Availability and implementation
The package rqt is freely available under the following link: https://github.com/izhbannikov/rqt.Contact
ilya.zhbannikov@duke.edu.Supplementary information
Supplementary data are available at Bioinformatics online.Full Text
Duke Authors
Cited Authors
- Zhbannikov, IY; Arbeev, KG; Yashin, AI
Published Date
- October 2017
Published In
Volume / Issue
- 33 / 19
Start / End Page
- 3129 - 3130
PubMed ID
- 28633423
Pubmed Central ID
- PMC5860520
Electronic International Standard Serial Number (EISSN)
- 1367-4811
International Standard Serial Number (ISSN)
- 1367-4803
Digital Object Identifier (DOI)
- 10.1093/bioinformatics/btx395
Language
- eng