Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.

Journal Article (Journal Article)

The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity. Notably, two isoforms of OPN exerted distinct effects in shifting this balance through cell-type-specific regulation of apoptosis. Intracellular OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (sOPN) increase the population size of lymphoid cells. The total effect of OPN on skewing the leukocyte population balance was observed as host sensitivity to early systemic infection with Candida albicans and T cell-mediated colitis. Our study suggests previously unknown detrimental roles for two OPN isoforms in causing the imbalance of leukocyte populations.

Full Text

Duke Authors

Cited Authors

  • Kanayama, M; Xu, S; Danzaki, K; Gibson, JR; Inoue, M; Gregory, SG; Shinohara, ML

Published Date

  • September 2017

Published In

Volume / Issue

  • 18 / 9

Start / End Page

  • 973 - 984

PubMed ID

  • 28671690

Pubmed Central ID

  • PMC5568448

Electronic International Standard Serial Number (EISSN)

  • 1529-2916

Digital Object Identifier (DOI)

  • 10.1038/ni.3791


  • eng

Conference Location

  • United States