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Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression.

Publication ,  Journal Article
Howitt, BE; Strickland, KC; Sholl, LM; Rodig, S; Ritterhouse, LL; Chowdhury, D; D'Andrea, AD; Matulonis, UA; Konstantinopoulos, PA
Published in: Oncoimmunology
2017

Clear cell ovarian carcinoma (CCOC) represents a distinct histologic subtype of ovarian cancer associated with significantly worse prognosis across all stages and no effective therapeutic options. Here, we report a rare but clinically important cohort of CCOCs with microsatellite instability (MSI) (MSI-CCOCs), which are highly immunogenic and may thus be very responsive to immune checkpoint blockade. CCOCs with MSI exhibit a significantly higher number of CD8+ TILs, higher CD8+/CD4+ ratio, and higher PD-1+ TILs compared with microsatellite stable (MSS) CCOCs and compared with high grade serous ovarian cancers, which are the most common histologic subtype of ovarian cancer. Of note, PD-L1 expression in tumor cells or immune cells was noted in all cases of CCOCs with MSI. These observations open an alternative therapeutic avenue for a fraction of patients with CCOC and argue for the routine testing of CCOCs for MSI, a test that is not currently routinely performed.

Duke Scholars

Published In

Oncoimmunology

DOI

ISSN

2162-4011

Publication Date

2017

Volume

6

Issue

2

Start / End Page

e1277308

Location

United States

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3204 Immunology
  • 1112 Oncology and Carcinogenesis
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Howitt, B. E., Strickland, K. C., Sholl, L. M., Rodig, S., Ritterhouse, L. L., Chowdhury, D., … Konstantinopoulos, P. A. (2017). Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression. Oncoimmunology, 6(2), e1277308. https://doi.org/10.1080/2162402X.2016.1277308
Howitt, Brooke E., Kyle C. Strickland, Lynette M. Sholl, Scott Rodig, Lauren L. Ritterhouse, Dipanjan Chowdhury, Alan D. D’Andrea, Ursula A. Matulonis, and Panagiotis A. Konstantinopoulos. “Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression.Oncoimmunology 6, no. 2 (2017): e1277308. https://doi.org/10.1080/2162402X.2016.1277308.
Howitt BE, Strickland KC, Sholl LM, Rodig S, Ritterhouse LL, Chowdhury D, et al. Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression. Oncoimmunology. 2017;6(2):e1277308.
Howitt, Brooke E., et al. “Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression.Oncoimmunology, vol. 6, no. 2, 2017, p. e1277308. Pubmed, doi:10.1080/2162402X.2016.1277308.
Howitt BE, Strickland KC, Sholl LM, Rodig S, Ritterhouse LL, Chowdhury D, D’Andrea AD, Matulonis UA, Konstantinopoulos PA. Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression. Oncoimmunology. 2017;6(2):e1277308.

Published In

Oncoimmunology

DOI

ISSN

2162-4011

Publication Date

2017

Volume

6

Issue

2

Start / End Page

e1277308

Location

United States

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3204 Immunology
  • 1112 Oncology and Carcinogenesis
  • 1107 Immunology