Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.

Journal Article (Journal Article)

Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational attainment is over-transmitted to children with ASD. These findings hold independent of proband IQ. We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly acting de novo variant. Lastly, we show that elements of polygenic risk are independent and differ in their relationship with phenotype. These results confirm that the genetic influences on ASD are additive and suggest that they create risk through at least partially distinct etiologic pathways.

Full Text

Duke Authors

Cited Authors

  • Weiner, DJ; Wigdor, EM; Ripke, S; Walters, RK; Kosmicki, JA; Grove, J; Samocha, KE; Goldstein, JI; Okbay, A; Bybjerg-Grauholm, J; Werge, T; Hougaard, DM; Taylor, J; iPSYCH-Broad Autism Group, ; Psychiatric Genomics Consortium Autism Group, ; Skuse, D; Devlin, B; Anney, R; Sanders, SJ; Bishop, S; Mortensen, PB; Børglum, AD; Smith, GD; Daly, MJ; Robinson, EB

Published Date

  • July 2017

Published In

Volume / Issue

  • 49 / 7

Start / End Page

  • 978 - 985

PubMed ID

  • 28504703

Pubmed Central ID

  • PMC5552240

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

Digital Object Identifier (DOI)

  • 10.1038/ng.3863


  • eng

Conference Location

  • United States