Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata.
Publication
, Journal Article
Dong, M; Quan, L-Q; Dai, W-F; Yan, S-L; Chen, C-H; Chen, X-Q; Li, R-T
Published in: Planta Med
November 2017
Three new compounds (1 - 3), including a sesterterpenoid, aspterpenacid C (1), with an unusual 5/3/7/6/5 pentacyclic skeleton, together with seven known ones (4 - 10), were isolated from the ethanol extract of the traditional Chinese medicinal plant Swertia bimaculata. Their structures were elucidated on the basis of the methods of spectroscopic NMR, MS, and computational chemistry. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis. Compounds 1 - 10 were tested for activities on the inhibition of nitric oxide production and HIV-1 replication in vitro. Compound 1 exhibited moderate activity in inhibiting nitric oxide production (IC50 = 16.1 µM) and HIV-1 replication (EC50 = 1.35 µM).
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Planta Med
DOI
EISSN
1439-0221
Publication Date
November 2017
Volume
83
Issue
17
Start / End Page
1368 / 1373
Location
Germany
Related Subject Headings
- Virus Replication
- Swertia
- RAW 264.7 Cells
- Nitric Oxide
- Molecular Structure
- Mice
- Medicinal & Biomolecular Chemistry
- HIV-1
- Drugs, Chinese Herbal
- China
Citation
APA
Chicago
ICMJE
MLA
NLM
Dong, M., Quan, L.-Q., Dai, W.-F., Yan, S.-L., Chen, C.-H., Chen, X.-Q., & Li, R.-T. (2017). Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata. Planta Med, 83(17), 1368–1373. https://doi.org/10.1055/s-0043-114736
Dong, Miao, Li-Qiu Quan, Wei-Feng Dai, Shi-Li Yan, Chin-Ho Chen, Xuan-Qin Chen, and Rong-Tao Li. “Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata.” Planta Med 83, no. 17 (November 2017): 1368–73. https://doi.org/10.1055/s-0043-114736.
Dong M, Quan L-Q, Dai W-F, Yan S-L, Chen C-H, Chen X-Q, et al. Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata. Planta Med. 2017 Nov;83(17):1368–73.
Dong, Miao, et al. “Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata.” Planta Med, vol. 83, no. 17, Nov. 2017, pp. 1368–73. Pubmed, doi:10.1055/s-0043-114736.
Dong M, Quan L-Q, Dai W-F, Yan S-L, Chen C-H, Chen X-Q, Li R-T. Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata. Planta Med. 2017 Nov;83(17):1368–1373.
Published In
Planta Med
DOI
EISSN
1439-0221
Publication Date
November 2017
Volume
83
Issue
17
Start / End Page
1368 / 1373
Location
Germany
Related Subject Headings
- Virus Replication
- Swertia
- RAW 264.7 Cells
- Nitric Oxide
- Molecular Structure
- Mice
- Medicinal & Biomolecular Chemistry
- HIV-1
- Drugs, Chinese Herbal
- China