Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata.

Published

Journal Article

Three new compounds (1 - 3), including a sesterterpenoid, aspterpenacid C (1), with an unusual 5/3/7/6/5 pentacyclic skeleton, together with seven known ones (4 - 10), were isolated from the ethanol extract of the traditional Chinese medicinal plant Swertia bimaculata. Their structures were elucidated on the basis of the methods of spectroscopic NMR, MS, and computational chemistry. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis. Compounds 1 - 10 were tested for activities on the inhibition of nitric oxide production and HIV-1 replication in vitro. Compound 1 exhibited moderate activity in inhibiting nitric oxide production (IC50 = 16.1 µM) and HIV-1 replication (EC50 = 1.35 µM).

Full Text

Duke Authors

Cited Authors

  • Dong, M; Quan, L-Q; Dai, W-F; Yan, S-L; Chen, C-H; Chen, X-Q; Li, R-T

Published Date

  • November 2017

Published In

Volume / Issue

  • 83 / 17

Start / End Page

  • 1368 - 1373

PubMed ID

  • 28662527

Pubmed Central ID

  • 28662527

Electronic International Standard Serial Number (EISSN)

  • 1439-0221

International Standard Serial Number (ISSN)

  • 0032-0943

Digital Object Identifier (DOI)

  • 10.1055/s-0043-114736

Language

  • eng