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Reasons for cesarean and medically indicated deliveries in pregnancies in women with systemic lupus erythematosus.

Publication ,  Journal Article
Eudy, AM; Jayasundara, M; Haroun, T; Neil, L; James, AH; Clowse, MEB
Published in: Lupus
March 2018

Objective To determine reasons for cesarean and medically indicated deliveries in a registry of pregnant women with SLE compared to RA. Methods Pregnant women with SLE or RA were prospectively followed, and pregnancy outcomes were collected, including whether labor was spontaneous or medically indicated and delivery was vaginal or cesarean. Preterm birth was defined as a birth <37 weeks gestation. Differences in reasons for cesarean delivery and indication of delivery between term and preterm births were determined by Fisher's exact test. Results Compared to RA pregnancies, SLE pregnancies had modestly higher rates of preterm birth (24% SLE vs 14% RA), pre-eclampsia (15% SLE vs 7% RA), and cesarean delivery (48% SLE vs 30% RA). The majority of preterm births among women with SLE were indicated (70%), most commonly for pre-eclampsia or the health of the infant or mother. The majority of preterm births among women with RA, however, were spontaneous, primarily due to premature rupture of membranes. Conclusion Pre-eclampsia and maternal SLE activity appear to be the key drivers for the high rate of preterm birth and medically indicated delivery in SLE. This contrasts with RA, where preterm labor is most often due to spontaneous onset of labor.

Duke Scholars

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Published In

Lupus

DOI

EISSN

1477-0962

Publication Date

March 2018

Volume

27

Issue

3

Start / End Page

351 / 356

Location

England

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Registries
  • Premature Birth
  • Pregnancy Outcome
  • Pregnancy Complications
  • Pregnancy
  • Pre-Eclampsia
  • North Carolina
  • Lupus Erythematosus, Systemic
 

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Eudy, A. M., Jayasundara, M., Haroun, T., Neil, L., James, A. H., & Clowse, M. E. B. (2018). Reasons for cesarean and medically indicated deliveries in pregnancies in women with systemic lupus erythematosus. Lupus, 27(3), 351–356. https://doi.org/10.1177/0961203317720525
Eudy, A. M., M. Jayasundara, T. Haroun, L. Neil, A. H. James, and M. E. B. Clowse. “Reasons for cesarean and medically indicated deliveries in pregnancies in women with systemic lupus erythematosus.Lupus 27, no. 3 (March 2018): 351–56. https://doi.org/10.1177/0961203317720525.
Eudy AM, Jayasundara M, Haroun T, Neil L, James AH, Clowse MEB. Reasons for cesarean and medically indicated deliveries in pregnancies in women with systemic lupus erythematosus. Lupus. 2018 Mar;27(3):351–6.
Eudy, A. M., et al. “Reasons for cesarean and medically indicated deliveries in pregnancies in women with systemic lupus erythematosus.Lupus, vol. 27, no. 3, Mar. 2018, pp. 351–56. Pubmed, doi:10.1177/0961203317720525.
Eudy AM, Jayasundara M, Haroun T, Neil L, James AH, Clowse MEB. Reasons for cesarean and medically indicated deliveries in pregnancies in women with systemic lupus erythematosus. Lupus. 2018 Mar;27(3):351–356.
Journal cover image

Published In

Lupus

DOI

EISSN

1477-0962

Publication Date

March 2018

Volume

27

Issue

3

Start / End Page

351 / 356

Location

England

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Registries
  • Premature Birth
  • Pregnancy Outcome
  • Pregnancy Complications
  • Pregnancy
  • Pre-Eclampsia
  • North Carolina
  • Lupus Erythematosus, Systemic