Management of hereditary antithrombin deficiency in pregnancy.


Journal Article

Antithrombin (AT) deficiency is a high-risk thrombophilia and a rare condition. Despite full anticoagulation during pregnancy and the postpartum period, women with AT deficiency may still be vulnerable to developing venous thromboembolism (VTE), including fatal events. There is limited guidance on the management of AT deficiency in pregnancy, including the role of AT concentrates. Following a comprehensive review of the state of the art with respect to recommendations and guidelines, our expert panel in maternal-fetal medicine, hematology and basic science reached consensus on key issues in the recognition and management of AT deficiency in pregnancy. This paper summarizes the state of the art and summarizes what we believe are best practices with special emphasis on a multidisciplinary approach involving obstetrics and hematology in the care of women with AT deficiency.

Full Text

Duke Authors

Cited Authors

  • James, AH; Bates, SM; Bauer, KA; Branch, W; Mann, K; Paidas, M; Silverman, N; Konkle, BA

Published Date

  • September 2017

Published In

Volume / Issue

  • 157 /

Start / End Page

  • 41 - 45

PubMed ID

  • 28689083

Pubmed Central ID

  • 28689083

Electronic International Standard Serial Number (EISSN)

  • 1879-2472

Digital Object Identifier (DOI)

  • 10.1016/j.thromres.2017.05.017


  • eng

Conference Location

  • United States