Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia.

Journal Article (Journal Article)

We describe a simple method of tracking oxygen in real-time with injectable, tissue-integrating microsensors. The sensors are small (500 μm × 500 μm × 5 mm), soft, flexible, tissue-like, biocompatible hydrogel s that have been shown to overcome the foreign body response for long-term sensing. The sensors are engineered to change luminescence in the presence of oxygen or other analytes and function for months to years in the body. A single injection followed by non-invasive monitoring with a hand-held or wearable Bluetooth optical reader enables intermittent or continuous measurements. Proof of concept for applications in high altitude, exercise physiology, vascular disease, stroke, tumors, and other disease states have been shown in mouse, rat and porcine models. Over 90 sensors have been studied to date in humans. These novel tissue-integrating sensors yield real-time insights in tissue oxygen fluctuations for research and clinical applications.

Full Text

Duke Authors

Cited Authors

  • Wisniewski, NA; Nichols, SP; Gamsey, SJ; Pullins, S; Au-Yeung, KY; Klitzman, B; Helton, KL

Published Date

  • 2017

Published In

Volume / Issue

  • 977 /

Start / End Page

  • 377 - 383

PubMed ID

  • 28685468

Pubmed Central ID

  • PMC5657483

International Standard Serial Number (ISSN)

  • 0065-2598

Digital Object Identifier (DOI)

  • 10.1007/978-3-319-55231-6_49


  • eng

Conference Location

  • United States