Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.


Journal Article

It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from resting tissues. More recently understood is that this metabolic phenotype is not unique to cancer cells but instead reflects characteristics of proliferating cells. Similar metabolic transitions also occur in the immune system as cells transition from resting state to stimulated effectors. A key finding in immune metabolism is that the metabolic programs of different cell subsets are distinctly associated with immunological function. Further, interruption of those metabolic pathways can shift immune cell fate to modulate immunity. These studies have identified numerous metabolic similarities between cancer and immune cells but also critical differences that may be exploited and that affect treatment of cancer and immunological diseases.

Full Text

Duke Authors

Cited Authors

  • Andrejeva, G; Rathmell, JC

Published Date

  • July 5, 2017

Published In

Volume / Issue

  • 26 / 1

Start / End Page

  • 49 - 70

PubMed ID

  • 28683294

Pubmed Central ID

  • 28683294

Electronic International Standard Serial Number (EISSN)

  • 1932-7420

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2017.06.004


  • eng

Conference Location

  • United States