Ten years later: a single hospital experience with malignancy in HIV/AIDS.


Journal Article

BACKGROUND AND OBJECTIVE: We present our experience in the era of HAART with 5,112 patients having HIV infection or AIDS, treated between 2002 and 2006 in our hospital, 182 of whom had malignancies (3.56%). We compared our findings to those from a similar cohort of patients studied 10 years earlier. METHODS: The charts were reviewed and data was electronically collected as in our 1993-1998 study. Similar statistical analyses were performed in both studies and the results were compared. RESULTS: For the current study the average patient age increased by 9 years. A decrease in AIDS-defining cancers (ADC), from 63.6% to 37.3% and a higher incidence of non-AIDS-defining cancers (NADC), 62.7 as opposed to 37.9% was found. No decrease in the incidence of non-Hodgkin's B cell lymphoma (NHL) was noted. There was an increase in the number of opportunistic infections notably hepatitis C virus (HCV) and hepatitis B virus (HBV). CONCLUSIONS: HIV/AIDS patients on HAART are older, have lower rates of AIDS related Kaposi's sarcoma and a higher incidence of NADCs than did patients in the early HAART era. No decrease in the proportion of NHL was observed.

Full Text

Duke Authors

Cited Authors

  • Reed, M; Cosgrove, JM; Cindrich, R; Parithivel, VS; Gad, Y; Bangalore, M; Uzor, R; Kalim, J; Segura, R; Albu, E

Published Date

  • September 2010

Published In

Volume / Issue

  • 102 / 3

Start / End Page

  • 282 - 286

PubMed ID

  • 20740588

Pubmed Central ID

  • 20740588

Electronic International Standard Serial Number (EISSN)

  • 1096-9098

International Standard Serial Number (ISSN)

  • 0022-4790

Digital Object Identifier (DOI)

  • 10.1002/jso.21590


  • eng