High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum.

Published

Journal Article

The cerebellum controls complex, coordinated, and rapid movements, a function requiring precise timing abilities. However, the network mechanisms that underlie the temporal organization of activity in the cerebellum are largely unexplored, because in vivo recordings have usually targeted single units. Here, we use tetrode and multisite recordings to demonstrate that Purkinje cell activity is synchronized by a high-frequency (approximately 200 Hz) population oscillation. We combine pharmacological experiments and modeling to show how the recurrent inhibitory connections between Purkinje cells are sufficient to generate these oscillations. A key feature of these oscillations is a fixed population frequency that is independent of the firing rates of the individual cells. Convergence in the deep cerebellar nuclei of Purkinje cell activity, synchronized by these oscillations, likely organizes temporally the cerebellar output.

Full Text

Duke Authors

Cited Authors

  • de Solages, C; Szapiro, G; Brunel, N; Hakim, V; Isope, P; Buisseret, P; Rousseau, C; Barbour, B; Léna, C

Published Date

  • June 12, 2008

Published In

Volume / Issue

  • 58 / 5

Start / End Page

  • 775 - 788

PubMed ID

  • 18549788

Pubmed Central ID

  • 18549788

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2008.05.008

Language

  • eng

Conference Location

  • United States