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High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum.

Publication ,  Journal Article
de Solages, C; Szapiro, G; Brunel, N; Hakim, V; Isope, P; Buisseret, P; Rousseau, C; Barbour, B; Léna, C
Published in: Neuron
June 12, 2008

The cerebellum controls complex, coordinated, and rapid movements, a function requiring precise timing abilities. However, the network mechanisms that underlie the temporal organization of activity in the cerebellum are largely unexplored, because in vivo recordings have usually targeted single units. Here, we use tetrode and multisite recordings to demonstrate that Purkinje cell activity is synchronized by a high-frequency (approximately 200 Hz) population oscillation. We combine pharmacological experiments and modeling to show how the recurrent inhibitory connections between Purkinje cells are sufficient to generate these oscillations. A key feature of these oscillations is a fixed population frequency that is independent of the firing rates of the individual cells. Convergence in the deep cerebellar nuclei of Purkinje cell activity, synchronized by these oscillations, likely organizes temporally the cerebellar output.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

June 12, 2008

Volume

58

Issue

5

Start / End Page

775 / 788

Location

United States

Related Subject Headings

  • Reaction Time
  • Rats, Wistar
  • Rats
  • Quinoxalines
  • Pyrazoles
  • Purkinje Cells
  • Piperidines
  • Picrotoxin
  • Neurology & Neurosurgery
  • Naphthalenes
 

Citation

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de Solages, C., Szapiro, G., Brunel, N., Hakim, V., Isope, P., Buisseret, P., … Léna, C. (2008). High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum. Neuron, 58(5), 775–788. https://doi.org/10.1016/j.neuron.2008.05.008
Solages, Camille de, Germán Szapiro, Nicolas Brunel, Vincent Hakim, Philippe Isope, Pierre Buisseret, Charly Rousseau, Boris Barbour, and Clément Léna. “High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum.Neuron 58, no. 5 (June 12, 2008): 775–88. https://doi.org/10.1016/j.neuron.2008.05.008.
de Solages C, Szapiro G, Brunel N, Hakim V, Isope P, Buisseret P, et al. High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum. Neuron. 2008 Jun 12;58(5):775–88.
de Solages, Camille, et al. “High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum.Neuron, vol. 58, no. 5, June 2008, pp. 775–88. Pubmed, doi:10.1016/j.neuron.2008.05.008.
de Solages C, Szapiro G, Brunel N, Hakim V, Isope P, Buisseret P, Rousseau C, Barbour B, Léna C. High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum. Neuron. 2008 Jun 12;58(5):775–788.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

June 12, 2008

Volume

58

Issue

5

Start / End Page

775 / 788

Location

United States

Related Subject Headings

  • Reaction Time
  • Rats, Wistar
  • Rats
  • Quinoxalines
  • Pyrazoles
  • Purkinje Cells
  • Piperidines
  • Picrotoxin
  • Neurology & Neurosurgery
  • Naphthalenes