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Astrocytes: Orchestrating synaptic plasticity?

Publication ,  Journal Article
De Pittà, M; Brunel, N; Volterra, A
Published in: Neuroscience
May 26, 2016

Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, the elucidation of its constituting mechanisms is of crucial importance in many aspects of normal and pathological brain function. In particular, a prominent aspect that remains debated is how the plasticity mechanisms, that encompass a broad spectrum of temporal and spatial scales, come to play together in a concerted fashion. Here we review and discuss evidence that pinpoints to a possible non-neuronal, glial candidate for such orchestration: the regulation of synaptic plasticity by astrocytes.

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Published In

Neuroscience

DOI

EISSN

1873-7544

Publication Date

May 26, 2016

Volume

323

Start / End Page

43 / 61

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Neurons
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Humans
  • Astrocytes
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences
 

Citation

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Chicago
ICMJE
MLA
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De Pittà, M., Brunel, N., & Volterra, A. (2016). Astrocytes: Orchestrating synaptic plasticity? Neuroscience, 323, 43–61. https://doi.org/10.1016/j.neuroscience.2015.04.001
De Pittà, M., N. Brunel, and A. Volterra. “Astrocytes: Orchestrating synaptic plasticity?Neuroscience 323 (May 26, 2016): 43–61. https://doi.org/10.1016/j.neuroscience.2015.04.001.
De Pittà M, Brunel N, Volterra A. Astrocytes: Orchestrating synaptic plasticity? Neuroscience. 2016 May 26;323:43–61.
De Pittà, M., et al. “Astrocytes: Orchestrating synaptic plasticity?Neuroscience, vol. 323, May 2016, pp. 43–61. Pubmed, doi:10.1016/j.neuroscience.2015.04.001.
De Pittà M, Brunel N, Volterra A. Astrocytes: Orchestrating synaptic plasticity? Neuroscience. 2016 May 26;323:43–61.
Journal cover image

Published In

Neuroscience

DOI

EISSN

1873-7544

Publication Date

May 26, 2016

Volume

323

Start / End Page

43 / 61

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Neurons
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Humans
  • Astrocytes
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences