Astrocytes: Orchestrating synaptic plasticity?

Journal Article (Journal Article;Review)

Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, the elucidation of its constituting mechanisms is of crucial importance in many aspects of normal and pathological brain function. In particular, a prominent aspect that remains debated is how the plasticity mechanisms, that encompass a broad spectrum of temporal and spatial scales, come to play together in a concerted fashion. Here we review and discuss evidence that pinpoints to a possible non-neuronal, glial candidate for such orchestration: the regulation of synaptic plasticity by astrocytes.

Full Text

Duke Authors

Cited Authors

  • De Pittà, M; Brunel, N; Volterra, A

Published Date

  • May 26, 2016

Published In

Volume / Issue

  • 323 /

Start / End Page

  • 43 - 61

PubMed ID

  • 25862587

Pubmed Central ID

  • 25862587

Electronic International Standard Serial Number (EISSN)

  • 1873-7544

Digital Object Identifier (DOI)

  • 10.1016/j.neuroscience.2015.04.001


  • eng

Conference Location

  • United States