Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study.

Journal Article (Journal Article)

Glutamatergic gliotransmission, that is, the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear. Here, we focus on two experimentally well-identified gliotransmitter pathways, (i) modulations of synaptic release and (ii) postsynaptic slow inward currents mediated by glutamate released from astrocytes, and investigate their possible functional relevance on synaptic plasticity in a biophysical model of an astrocyte-regulated synapse. Our model predicts that both pathways could profoundly affect both short- and long-term plasticity. In particular, activity-dependent glutamate release from astrocytes could dramatically change spike-timing-dependent plasticity, turning potentiation into depression (and vice versa) for the same induction protocol.

Full Text

Duke Authors

Cited Authors

  • De Pittà, M; Brunel, N

Published Date

  • 2016

Published In

Volume / Issue

  • 2016 /

Start / End Page

  • 7607924 -

PubMed ID

  • 27195153

Pubmed Central ID

  • PMC4852535

Electronic International Standard Serial Number (EISSN)

  • 1687-5443

Digital Object Identifier (DOI)

  • 10.1155/2016/7607924


  • eng

Conference Location

  • United States