Electrical coupling mediates tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network.

Published

Journal Article

Tonic motor control involves oscillatory synchronization of activity at low frequency (5-30 Hz) throughout the sensorimotor system, including cerebellar areas. We investigated the mechanisms underpinning cerebellar oscillations. We found that Golgi interneurons, which gate information transfer in the cerebellar cortex input layer, are extensively coupled through electrical synapses. When depolarized in vitro, these neurons displayed low-frequency oscillatory synchronization, imposing rhythmic inhibition onto granule cells. Combining experiments and modeling, we show that electrical transmission of the spike afterhyperpolarization is the essential component for oscillatory population synchronization. Rhythmic firing arises in spite of strong heterogeneities, is frequency tuned by the mean excitatory input to Golgi cells, and displays pronounced resonance when the modeled network is driven by oscillating inputs. In vivo, unitary Golgi cell activity was found to synchronize with low-frequency LFP oscillations occurring during quiet waking. These results suggest a major role for Golgi cells in coordinating cerebellar sensorimotor integration during oscillatory interactions.

Full Text

Duke Authors

Cited Authors

  • Dugué, GP; Brunel, N; Hakim, V; Schwartz, E; Chat, M; Lévesque, M; Courtemanche, R; Léna, C; Dieudonné, S

Published Date

  • January 15, 2009

Published In

Volume / Issue

  • 61 / 1

Start / End Page

  • 126 - 139

PubMed ID

  • 19146818

Pubmed Central ID

  • 19146818

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2008.11.028

Language

  • eng

Conference Location

  • United States