Effects of synaptic noise and filtering on the frequency response of spiking neurons.

Published

Journal Article

Noise can have a significant impact on the response dynamics of a nonlinear system. For neurons, the primary source of noise comes from background synaptic input activity. If this is approximated as white noise, the amplitude of the modulation of the firing rate in response to an input current oscillating at frequency omega decreases as 1/square root[omega] and lags the input by 45 degrees in phase. However, if filtering due to realistic synaptic dynamics is included, the firing rate is modulated by a finite amount even in the limit omega-->infinity and the phase lag is eliminated. Thus, through its effect on noise inputs, realistic synaptic dynamics can ensure unlagged neuronal responses to high-frequency inputs.

Full Text

Duke Authors

Cited Authors

  • Brunel, N; Chance, FS; Fourcaud, N; Abbott, LF

Published Date

  • March 2001

Published In

Volume / Issue

  • 86 / 10

Start / End Page

  • 2186 - 2189

PubMed ID

  • 11289886

Pubmed Central ID

  • 11289886

Electronic International Standard Serial Number (EISSN)

  • 1079-7114

International Standard Serial Number (ISSN)

  • 0031-9007

Digital Object Identifier (DOI)

  • 10.1103/physrevlett.86.2186

Language

  • eng