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Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit.

Publication ,  Journal Article
Zampini, V; Liu, JK; Diana, MA; Maldonado, PP; Brunel, N; Dieudonné, S
Published in: Elife
September 19, 2016

Synaptic currents display a large degree of heterogeneity of their temporal characteristics, but the functional role of such heterogeneities remains unknown. We investigated in rat cerebellar slices synaptic currents in Unipolar Brush Cells (UBCs), which generate intrinsic mossy fibers relaying vestibular inputs to the cerebellar cortex. We show that UBCs respond to sinusoidal modulations of their sensory input with heterogeneous amplitudes and phase shifts. Experiments and modeling indicate that this variability results both from the kinetics of synaptic glutamate transients and from the diversity of postsynaptic receptors. While phase inversion is produced by an mGluR2-activated outward conductance in OFF-UBCs, the phase delay of ON UBCs is caused by a late rebound current resulting from AMPAR recovery from desensitization. Granular layer network modeling indicates that phase dispersion of UBC responses generates diverse phase coding in the granule cell population, allowing climbing-fiber-driven Purkinje cell learning at arbitrary phases of the vestibular input.

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Published In

Elife

DOI

EISSN

2050-084X

Publication Date

September 19, 2016

Volume

5

Location

England

Related Subject Headings

  • Vestibule, Labyrinth
  • Receptors, Glutamate
  • Rats
  • Nerve Net
  • Nerve Fibers
  • Models, Neurological
  • Glutamic Acid
  • Excitatory Amino Acid Agents
  • Cerebellar Cortex
  • Animals
 

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Zampini, V., Liu, J. K., Diana, M. A., Maldonado, P. P., Brunel, N., & Dieudonné, S. (2016). Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit. Elife, 5. https://doi.org/10.7554/eLife.15872
Zampini, Valeria, Jian K. Liu, Marco A. Diana, Paloma P. Maldonado, Nicolas Brunel, and Stéphane Dieudonné. “Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit.Elife 5 (September 19, 2016). https://doi.org/10.7554/eLife.15872.
Zampini V, Liu JK, Diana MA, Maldonado PP, Brunel N, Dieudonné S. Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit. Elife. 2016 Sep 19;5.
Zampini, Valeria, et al. “Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit.Elife, vol. 5, Sept. 2016. Pubmed, doi:10.7554/eLife.15872.
Zampini V, Liu JK, Diana MA, Maldonado PP, Brunel N, Dieudonné S. Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit. Elife. 2016 Sep 19;5.

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

September 19, 2016

Volume

5

Location

England

Related Subject Headings

  • Vestibule, Labyrinth
  • Receptors, Glutamate
  • Rats
  • Nerve Net
  • Nerve Fibers
  • Models, Neurological
  • Glutamic Acid
  • Excitatory Amino Acid Agents
  • Cerebellar Cortex
  • Animals