Models for recovering the energy landscape of conformational transitions from single-molecule pulling experiments

Published

Journal Article

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Single-molecule force spectroscopy is a powerful experimental technique for probing intermolecular forces and conformational transitions of individual molecules. This technique involves measuring the mechanical response of a molecule subjected to a constant or time-varying force. Statistical mechanics has played a pivotal role in interpreting force measurements in terms of the underlying kinetics and energy landscape of the molecular transition being studied. Here, we provide a didactic review of various statistical–mechanical models used for analysing these measurements, emphasising the theoretical ideas and assumptions used in deriving these models.

Full Text

Duke Authors

Cited Authors

  • Arya, G

Published Date

  • September 1, 2016

Published In

Volume / Issue

  • 42 / 13

Start / End Page

  • 1102 - 1115

Electronic International Standard Serial Number (EISSN)

  • 1029-0435

International Standard Serial Number (ISSN)

  • 0892-7022

Digital Object Identifier (DOI)

  • 10.1080/08927022.2015.1123257

Citation Source

  • Scopus