False positivity of monospot test in an immunocompetent elderly woman with acute cytomegalovirus infection.


Journal Article

A 75-year-old woman presented with altered mental status, septic picture, and influenza-like symptoms. Initial investigations revealed atypical lymphocytosis, thrombocytopenia, elevated liver enzymes, and a positive monospot test result. Further investigation showed the Epstein-Barr virus viral capsid antibody IgM/IgG and Epstein-Barr virus DNA by polymerase chain reaction to be negative; however, interestingly her cytomegalovirus (CMV) IgM and IgG were positive, suggesting that her mononucleosis-like syndrome was due to acute CMV infection. Herein, we report the first case of a heterophile-positive mononucleosis syndrome caused by acute CMV infection in an elderly immunocompetent woman. This case conveys that monospot test can yield false-positive result in the setting of acute CMV infection.

Full Text

Cited Authors

  • Thamcharoen, N; Sornprom, S; Permpalung, N; Hyman, CL

Published Date

  • October 2015

Published In

Volume / Issue

  • 33 / 10

Start / End Page

  • 1544.e1 - 1544.e2

PubMed ID

  • 26275628

Pubmed Central ID

  • 26275628

Electronic International Standard Serial Number (EISSN)

  • 1532-8171

Digital Object Identifier (DOI)

  • 10.1016/j.ajem.2015.07.028


  • eng

Conference Location

  • United States