Analysis of Dengue Serotype 4 in Sri Lanka during the 2012-2013 Dengue Epidemic.

Journal Article (Journal Article)

The four serotypes of dengue virus (DENV-1, -2, -3, and -4) have had a rapidly expanding geographic range and are now endemic in over 100 tropical and subtropical countries. Sri Lanka has experienced periodic dengue outbreaks since the 1960s, but since 1989 epidemics have become progressively larger and associated with more severe disease. The dominant virus in the 2012 epidemic was DENV-1, but DENV-4 infections were also commonly observed. DENV-4 transmission was first documented in Sri Lanka when it was isolated from a traveler in 1978, but has been comparatively uncommon since dengue surveillance began in the early 1980s. To better understand the molecular epidemiology of DENV-4 infections in Sri Lanka, we conducted whole-genome sequencing on dengue patient samples from two different geographic locations. Phylogenetic analysis indicates that all sequenced DENV-4 strains belong to genotype 1 and are most closely related to DENV-4 viruses previously found in Sri Lanka and those recently found to be circulating in India and Pakistan.

Full Text

Duke Authors

Cited Authors

  • Uehara, A; Tissera, HA; Bodinayake, CK; Amarasinghe, A; Nagahawatte, A; Tillekeratne, LG; Cui, J; Reller, ME; Palihawadana, P; Gunasena, S; Desilva, AD; Wilder-Smith, A; Gubler, DJ; Woods, CW; Sessions, OM

Published Date

  • July 2017

Published In

Volume / Issue

  • 97 / 1

Start / End Page

  • 130 - 136

PubMed ID

  • 28719296

Pubmed Central ID

  • PMC5508889

Electronic International Standard Serial Number (EISSN)

  • 1476-1645

International Standard Serial Number (ISSN)

  • 0002-9637

Digital Object Identifier (DOI)

  • 10.4269/ajtmh.16-0540


  • eng