Pulmonary hypoplasia.

Journal Article (Journal Article;Review)

To survive the transition to extrauterine life, newborn infants must have lungs that provide an adequate surface area and volume to allow for gas exchange. The dynamic activities of fetal breathing movements and accumulation of lung luminal fluid are key to fetal lung development throughout the various phases of lung development and growth, first by branching morphogenesis, and later by septation. Because effective gas exchange is essential to survival, pulmonary hypoplasia is among the leading findings on autopsies of children dying in the newborn period. Management of infants born prematurely who had disrupted lung development, especially at the pre-glandular or canalicular periods, may be challenging, but limited success has been reported. Growing understanding of stem cell biology and mechanical development of the lung, and how to apply them clinically, may lead to new approaches that will lead to better outcomes for these patients.

Full Text

Duke Authors

Cited Authors

  • Cotten, CM

Published Date

  • August 2017

Published In

Volume / Issue

  • 22 / 4

Start / End Page

  • 250 - 255

PubMed ID

  • 28709949

Electronic International Standard Serial Number (EISSN)

  • 1878-0946

Digital Object Identifier (DOI)

  • 10.1016/j.siny.2017.06.004


  • eng

Conference Location

  • Netherlands