Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve.

Published

Journal Article

Correct myelination is crucial for the function of the peripheral nervous system. Both positive and negative regulators within the axon and Schwann cell function to ensure the correct onset and progression of myelination during both development and following peripheral nerve injury and repair. The Sox2 transcription factor is well known for its roles in the development and maintenance of progenitor and stem cell populations, but has also been proposed in vitro as a negative regulator of myelination in Schwann cells. We wished to test fully whether Sox2 regulates myelination in vivo and show here that, in mice, sustained Sox2 expression in vivo blocks myelination in the peripheral nerves and maintains Schwann cells in a proliferative non-differentiated state, which is also associated with increased inflammation within the nerve. The plasticity of Schwann cells allows them to re-myelinate regenerated axons following injury and we show that re-myelination is also blocked by Sox2 expression in Schwann cells. These findings identify Sox2 as a physiological regulator of Schwann cell myelination in vivo and its potential to play a role in disorders of myelination in the peripheral nervous system.

Full Text

Duke Authors

Cited Authors

  • Roberts, SL; Dun, X-P; Doddrell, RDS; Mindos, T; Drake, LK; Onaitis, MW; Florio, F; Quattrini, A; Lloyd, AC; D'Antonio, M; Parkinson, DB

Published Date

  • September 2017

Published In

Volume / Issue

  • 144 / 17

Start / End Page

  • 3114 - 3125

PubMed ID

  • 28743796

Pubmed Central ID

  • 28743796

Electronic International Standard Serial Number (EISSN)

  • 1477-9129

International Standard Serial Number (ISSN)

  • 0950-1991

Digital Object Identifier (DOI)

  • 10.1242/dev.150656

Language

  • eng