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Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve.

Publication ,  Journal Article
Roberts, SL; Dun, X-P; Doddrell, RDS; Mindos, T; Drake, LK; Onaitis, MW; Florio, F; Quattrini, A; Lloyd, AC; D'Antonio, M; Parkinson, DB
Published in: Development
September 1, 2017

Correct myelination is crucial for the function of the peripheral nervous system. Both positive and negative regulators within the axon and Schwann cell function to ensure the correct onset and progression of myelination during both development and following peripheral nerve injury and repair. The Sox2 transcription factor is well known for its roles in the development and maintenance of progenitor and stem cell populations, but has also been proposed in vitro as a negative regulator of myelination in Schwann cells. We wished to test fully whether Sox2 regulates myelination in vivo and show here that, in mice, sustained Sox2 expression in vivo blocks myelination in the peripheral nerves and maintains Schwann cells in a proliferative non-differentiated state, which is also associated with increased inflammation within the nerve. The plasticity of Schwann cells allows them to re-myelinate regenerated axons following injury and we show that re-myelination is also blocked by Sox2 expression in Schwann cells. These findings identify Sox2 as a physiological regulator of Schwann cell myelination in vivo and its potential to play a role in disorders of myelination in the peripheral nervous system.

Duke Scholars

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Published In

Development

DOI

EISSN

1477-9129

Publication Date

September 1, 2017

Volume

144

Issue

17

Start / End Page

3114 / 3125

Location

England

Related Subject Headings

  • beta Catenin
  • Transgenes
  • Schwann Cells
  • SOXB1 Transcription Factors
  • Recovery of Function
  • Rats
  • Proto-Oncogene Proteins c-jun
  • Peripheral Nerves
  • Peripheral Nerve Injuries
  • Neural Conduction
 

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Roberts, S. L., Dun, X.-P., Doddrell, R. D. S., Mindos, T., Drake, L. K., Onaitis, M. W., … Parkinson, D. B. (2017). Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve. Development, 144(17), 3114–3125. https://doi.org/10.1242/dev.150656
Roberts, Sheridan L., Xin-Peng Dun, Robin D. S. Doddrell, Thomas Mindos, Louisa K. Drake, Mark W. Onaitis, Francesca Florio, et al. “Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve.Development 144, no. 17 (September 1, 2017): 3114–25. https://doi.org/10.1242/dev.150656.
Roberts SL, Dun X-P, Doddrell RDS, Mindos T, Drake LK, Onaitis MW, et al. Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve. Development. 2017 Sep 1;144(17):3114–25.
Roberts, Sheridan L., et al. “Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve.Development, vol. 144, no. 17, Sept. 2017, pp. 3114–25. Pubmed, doi:10.1242/dev.150656.
Roberts SL, Dun X-P, Doddrell RDS, Mindos T, Drake LK, Onaitis MW, Florio F, Quattrini A, Lloyd AC, D’Antonio M, Parkinson DB. Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve. Development. 2017 Sep 1;144(17):3114–3125.
Journal cover image

Published In

Development

DOI

EISSN

1477-9129

Publication Date

September 1, 2017

Volume

144

Issue

17

Start / End Page

3114 / 3125

Location

England

Related Subject Headings

  • beta Catenin
  • Transgenes
  • Schwann Cells
  • SOXB1 Transcription Factors
  • Recovery of Function
  • Rats
  • Proto-Oncogene Proteins c-jun
  • Peripheral Nerves
  • Peripheral Nerve Injuries
  • Neural Conduction