Zevalin(®) (ibritumomab tiuxetan): After more than a decade of treatment experience, what have we learned?


Journal Article (Review)

Non-Hodgkin's lymphoma (NHL) comprises a clinically and biologically heterogeneous group of lymphoproliferative disorders originating in B lymphocytes, T lymphocytes, or natural killer (NK) cells. The disease course may range from indolent to aggressive. Zevalin(®) (ibritumomab tiuxetan) is a radioactive drug product, which is the combination of a β-emitting isotope, (90)Y, linked to the anti-CD20 monoclonal antibody (mAb), rituximab. It has demonstrated therapeutic efficacy with durable responses and allows delivery of ionizing radiation directly to the tumor site, while minimizing toxicity to normal tissue. Ibritumomab tiuxetan is indicated for treatment of patients with relapsed or refractory low-grade, follicular NHL, including patients who are refractory to rituximab, and as consolidation therapy in previously untreated follicular NHL in patients who achieve a partial or complete response to first-line chemotherapy. Despite the efficacy and acceptable safety profile of ibritumomab tiuxetan, utilization has not been broadly adopted in practice due to a number of factors. This manuscript will review the literature available for ibritumomab tiuxetan, including several new trials that are currently being studied, and discuss the rationale for use of ibritumomab tiuxetan in NHL.

Full Text

Duke Authors

Cited Authors

  • Rizzieri, D

Published Date

  • September 2016

Published In

Volume / Issue

  • 105 /

Start / End Page

  • 5 - 17

PubMed ID

  • 27497027

Pubmed Central ID

  • 27497027

Electronic International Standard Serial Number (EISSN)

  • 1879-0461

Digital Object Identifier (DOI)

  • 10.1016/j.critrevonc.2016.07.008


  • eng

Conference Location

  • Netherlands