Iron absorption in the thalassemia syndromes and its inhibition by tea.

Published

Journal Article

To determine the hemoglobin concentration at which iron absorption is minimal, five subjects with thalassemia major and one with thalassemia intermedia underwent a series of iron-absorption studies. The effect of tea as an inhibitor of non-heme iron absorption was also tested. Iron absorption increased as the hemoglobin concentration decreased, although iron absorption was much higher at any given hemoglobin level in the subject with thalassemia intermedia. In the subjects with thalassemia major, iron absorption averaged 10 per cent at hemoglobin concentrations between 9 and 10 and 2.7 per cent between 11 and 13 g per deciliter. The percentage of iron absorbed could be accurately predicted from the nucleated red-cell count (r = 0.91, P less than 0.001). Tea produced a 41 to 95 per cent inhibition of iron absorption. Since patients with thalassemia intermedia may absorb a large percentage of dietary iron, inhibitors of iron absorption, such as tea, may be useful in their management.

Full Text

Duke Authors

Cited Authors

  • de Alarcon, PA; Donovan, ME; Forbes, GB; Landaw, SA; Stockman, JA

Published Date

  • January 4, 1979

Published In

Volume / Issue

  • 300 / 1

Start / End Page

  • 5 - 8

PubMed ID

  • 758174

Pubmed Central ID

  • 758174

International Standard Serial Number (ISSN)

  • 0028-4793

Digital Object Identifier (DOI)

  • 10.1056/NEJM197901043000102

Language

  • eng

Conference Location

  • United States