Body mass index mediates the prognostic significance of circulating tumor cells in inflammatory breast cancer.


Journal Article

BACKGROUND: Obesity (BMI≥30) may be an etiologic and prognostic factor in inflammatory breast cancer (IBC). We examined the relationship between BMI, pathologic complete response (pCR), and circulating-tumor-cell (CTC) levels in IBC. METHODS: Cohort included IBC patients diagnosed 2005-2015 who had neoadjuvant chemotherapy during a prospective trial on CTCs and pathologic review describing pCR. Chi-square, logistic regression, and Cox proportional hazards models were used to identify clinicopathologic associations with event-free survival (EFS). RESULTS: Of 73 patients, 61 (84%) had CTC values, 22 (30%) achieved a pCR, and 39 (53%) were obese. There was no difference between obese and non-obese patients for pCR rates (31% vs. 29%, p = 0.90) or presence of CTCs (23% vs. 26%, p = 0.80). Among non-obese patients, CTCs were associated with worse EFS (HR 11.69, p < 0.01), but among obese patients, there was no difference in EFS between those with and without CTCs. CONCLUSIONS: BMI mediates CTCs' prognostic significance in IBC.

Full Text

Duke Authors

Cited Authors

  • Fayanju, OM; Hall, CS; Bauldry, JB; Karhade, M; Valad, LM; Kuerer, HM; DeSnyder, SM; Barcenas, CH; Lucci, A

Published Date

  • October 2017

Published In

Volume / Issue

  • 214 / 4

Start / End Page

  • 666 - 671

PubMed ID

  • 28720217

Pubmed Central ID

  • 28720217

Electronic International Standard Serial Number (EISSN)

  • 1879-1883

Digital Object Identifier (DOI)

  • 10.1016/j.amjsurg.2017.06.005


  • eng

Conference Location

  • United States