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Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children.

Publication ,  Journal Article
Hsu, L-I; Chokkalingam, AP; Briggs, FBS; Walsh, K; Crouse, V; Fu, C; Metayer, C; Wiemels, JL; Barcellos, LF; Buffler, PA
Published in: Cancer Causes Control
April 2015

BACKGROUND: Genome-wide association studies focusing on European-ancestry populations have identified ALL risk loci on IKZF1, ARID5B, and CEBPE. To capture the impacts of these genes on ALL risk in the California Hispanic population, we comprehensively assessed the variation within the genes and further assessed the joint effects between the genetic variation and surrogates for early-life infections (the presence of older siblings, daycare attendance, and ear infections). METHODS: Genotypic data for 323 Hispanic ALL cases and 454 controls from the California Childhood Leukemia Study were generated using Illumina OmniExpress v1 platform. Logistic regression assuming a log-additive model estimated odds ratios (OR) associated with each SNP, adjusted for age, sex, and the first five principal components. In addition, we examined potential interactions between six ALL risk alleles and surrogates for early-life infections using logistic regression models that included an interaction term. RESULTS: Significant associations between genotypes at IKZF1, ARID5B, and CEBPE and ALL risk were identified: rs7780012, OR 0.50, 95% confidence interval (CI) 0.35-0.71 (p = 0.004); rs7089424, OR 2.12, 95% CI 1.70-2.65 (p = 1.16 × 10(-9)); rs4982731, OR 1.69, 95% CI 1.37-2.08 (p = 2.35 × 10(-6)), respectively. Evidence for multiplicative interactions between genetic variants and surrogates for early-life infections with ALL risk was not observed. CONCLUSIONS: Consistent with findings in non-Hispanic White population, our study showed that variants within IKZF1, ARID5B, and CEBPE were associated with increased ALL risk, and the effects for ARID5B and CEBPE were most prominent in the high-hyperdiploid ALL subtype in the California Hispanic population. Results implicate the ARID5B, CEBPE, and IKZF1 genes in the pathogenesis of childhood ALL.

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Published In

Cancer Causes Control

DOI

EISSN

1573-7225

Publication Date

April 2015

Volume

26

Issue

4

Start / End Page

609 / 619

Location

Netherlands

Related Subject Headings

  • Transcription Factors
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Polymorphism, Single Nucleotide
  • Male
  • Logistic Models
  • Infant
  • Ikaros Transcription Factor
  • Humans
  • Hispanic or Latino
  • Genotype
 

Citation

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Chicago
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Hsu, L.-I., Chokkalingam, A. P., Briggs, F. B. S., Walsh, K., Crouse, V., Fu, C., … Buffler, P. A. (2015). Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children. Cancer Causes Control, 26(4), 609–619. https://doi.org/10.1007/s10552-015-0550-3
Hsu, Ling-I, Anand P. Chokkalingam, Farren B. S. Briggs, Kyle Walsh, Vonda Crouse, Cecilia Fu, Catherine Metayer, Joseph L. Wiemels, Lisa F. Barcellos, and Patricia A. Buffler. “Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children.Cancer Causes Control 26, no. 4 (April 2015): 609–19. https://doi.org/10.1007/s10552-015-0550-3.
Hsu L-I, Chokkalingam AP, Briggs FBS, Walsh K, Crouse V, Fu C, et al. Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children. Cancer Causes Control. 2015 Apr;26(4):609–19.
Hsu, Ling-I., et al. “Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children.Cancer Causes Control, vol. 26, no. 4, Apr. 2015, pp. 609–19. Pubmed, doi:10.1007/s10552-015-0550-3.
Hsu L-I, Chokkalingam AP, Briggs FBS, Walsh K, Crouse V, Fu C, Metayer C, Wiemels JL, Barcellos LF, Buffler PA. Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children. Cancer Causes Control. 2015 Apr;26(4):609–619.
Journal cover image

Published In

Cancer Causes Control

DOI

EISSN

1573-7225

Publication Date

April 2015

Volume

26

Issue

4

Start / End Page

609 / 619

Location

Netherlands

Related Subject Headings

  • Transcription Factors
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Polymorphism, Single Nucleotide
  • Male
  • Logistic Models
  • Infant
  • Ikaros Transcription Factor
  • Humans
  • Hispanic or Latino
  • Genotype