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Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.

Publication ,  Journal Article
Walsh, KM; Codd, V; Smirnov, IV; Rice, T; Decker, PA; Hansen, HM; Kollmeyer, T; Kosel, ML; Molinaro, AM; McCoy, LS; Bracci, PM; Cabriga, BS ...
Published in: Nat Genet
July 2014

Glioma, the most common central nervous system cancer in adults, has poor prognosis. Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that reached genome-wide significance (Pcombined = 8.3 × 10(-9)) in a meta-analysis of genome-wide association studies (GWAS) of high-grade glioma and replication data (1,644 cases and 7,736 controls). This region has previously been associated with mean leukocyte telomere length (LTL). We therefore examined the relationship between LTL and both this new risk locus and other previously established risk loci for glioma using data from a recent GWAS of LTL (n = 37,684 individuals). Alleles associated with glioma risk near TERC and TERT were strongly associated with longer LTL (P = 5.5 × 10(-20) and 4.4 × 10(-19), respectively). In contrast, risk-associated alleles near RTEL1 were inconsistently associated with LTL, suggesting the presence of distinct causal alleles. No other risk loci for glioma were associated with LTL. The identification of risk alleles for glioma near TERC and TERT that also associate with telomere length implicates telomerase in gliomagenesis.

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

July 2014

Volume

46

Issue

7

Start / End Page

731 / 735

Location

United States

Related Subject Headings

  • Telomere
  • Telomerase
  • Risk Factors
  • RNA
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Neoplasm Grading
  • Leukocytes
  • Humans
  • Glioma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Walsh, K. M., Codd, V., Smirnov, I. V., Rice, T., Decker, P. A., Hansen, H. M., … Wrensch, M. R. (2014). Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet, 46(7), 731–735. https://doi.org/10.1038/ng.3004
Walsh, Kyle M., Veryan Codd, Ivan V. Smirnov, Terri Rice, Paul A. Decker, Helen M. Hansen, Thomas Kollmeyer, et al. “Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.Nat Genet 46, no. 7 (July 2014): 731–35. https://doi.org/10.1038/ng.3004.
Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, et al. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014 Jul;46(7):731–5.
Walsh, Kyle M., et al. “Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.Nat Genet, vol. 46, no. 7, July 2014, pp. 731–35. Pubmed, doi:10.1038/ng.3004.
Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang SM, Prados MD, Lachance DH, O’Neill BP, Sicotte H, Eckel-Passow JE, ENGAGE Consortium Telomere Group, van der Harst P, Wiencke JK, Samani NJ, Jenkins RB, Wrensch MR. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014 Jul;46(7):731–735.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

July 2014

Volume

46

Issue

7

Start / End Page

731 / 735

Location

United States

Related Subject Headings

  • Telomere
  • Telomerase
  • Risk Factors
  • RNA
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Neoplasm Grading
  • Leukocytes
  • Humans
  • Glioma