Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation.
Transdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. In this study, we have used a laser-based printing approach known as matrix-assisted pulsed laser evaporation to print amphotericin B on the surfaces of polyglycolic acid microneedles that were prepared using a combination of injection molding and drawing lithography. In a modified agar disk diffusion assay, the amphotericin B-loaded microneedles showed concentration-dependent activity against the yeast Candida albicans. The results of this study suggest that matrix-assisted pulsed laser evaporation may be used to print amphotericin B and other drugs that have complex solubility issues on the surfaces of microneedles.
Sachan, R; Jaipan, P; Zhang, JY; Degan, S; Erdmann, D; Tedesco, J; Vanderwal, L; Stafslien, SJ; Negut, I; Visan, A; Dorcioman, G; Socol, G; Cristescu, R; Chrisey, DB; Narayan, RJ
Volume / Issue
Start / End Page
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)