Skip to main content
Journal cover image

PECAM-1: regulator of endothelial junctional integrity.

Publication ,  Journal Article
Privratsky, JR; Newman, PJ
Published in: Cell Tissue Res
March 2014

PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprising six extracellular immunoglobulin (Ig)-like homology domains, a short transmembrane domain and a 118 amino acid cytoplasmic domain that becomes serine and tyrosine phosphorylated upon cellular activation. PECAM-1 expression is restricted to blood and vascular cells. In circulating platelets and leukocytes, PECAM-1 functions largely as an inhibitory receptor that, via regulated sequential phosphorylation of its cytoplasmic domain, limits cellular activation responses. PECAM-1 is also highly expressed at endothelial cell intercellular junctions, where it functions as a mechanosensor, as a regulator of leukocyte trafficking and in the maintenance of endothelial cell junctional integrity. In this review, we will describe (1) the functional domains of PECAM-1 and how they contribute to its barrier-enhancing properties, (2) how the physical properties of PECAM-1 influence its subcellular localization and its ability to influence endothelial cell barrier function, (3) various stimuli that initiate PECAM-1 signaling and/or function at the endothelial junction and (4) cross-talk of PECAM-1 with other junctional molecules, which can influence endothelial cell function.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell Tissue Res

DOI

EISSN

1432-0878

Publication Date

March 2014

Volume

355

Issue

3

Start / End Page

607 / 619

Location

Germany

Related Subject Headings

  • Platelet Endothelial Cell Adhesion Molecule-1
  • Neurology & Neurosurgery
  • Intercellular Junctions
  • Humans
  • Endothelial Cells
  • Cell Adhesion
  • Animals
  • 3208 Medical physiology
  • 1116 Medical Physiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Privratsky, J. R., & Newman, P. J. (2014). PECAM-1: regulator of endothelial junctional integrity. Cell Tissue Res, 355(3), 607–619. https://doi.org/10.1007/s00441-013-1779-3
Privratsky, Jamie R., and Peter J. Newman. “PECAM-1: regulator of endothelial junctional integrity.Cell Tissue Res 355, no. 3 (March 2014): 607–19. https://doi.org/10.1007/s00441-013-1779-3.
Privratsky JR, Newman PJ. PECAM-1: regulator of endothelial junctional integrity. Cell Tissue Res. 2014 Mar;355(3):607–19.
Privratsky, Jamie R., and Peter J. Newman. “PECAM-1: regulator of endothelial junctional integrity.Cell Tissue Res, vol. 355, no. 3, Mar. 2014, pp. 607–19. Pubmed, doi:10.1007/s00441-013-1779-3.
Privratsky JR, Newman PJ. PECAM-1: regulator of endothelial junctional integrity. Cell Tissue Res. 2014 Mar;355(3):607–619.
Journal cover image

Published In

Cell Tissue Res

DOI

EISSN

1432-0878

Publication Date

March 2014

Volume

355

Issue

3

Start / End Page

607 / 619

Location

Germany

Related Subject Headings

  • Platelet Endothelial Cell Adhesion Molecule-1
  • Neurology & Neurosurgery
  • Intercellular Junctions
  • Humans
  • Endothelial Cells
  • Cell Adhesion
  • Animals
  • 3208 Medical physiology
  • 1116 Medical Physiology