Receptors, channels, and signalling in the urothelial sensory system in the bladder.

Published

Journal Article (Review)

The storage and periodic elimination of urine, termed micturition, requires a complex neural control system to coordinate the activities of the urinary bladder, urethra, and urethral sphincters. At the level of the lumbosacral spinal cord, lower urinary tract reflex mechanisms are modulated by supraspinal controls with mechanosensory input from the urothelium, resulting in regulation of bladder contractile activity. The specific identity of the mechanical sensor is not yet known, but considerable interest exists in the contribution of transient receptor potential (TRP) channels to the mechanosensory functions of the urothelium. The sensory, transduction, and signalling properties of the urothelium can influence adjacent urinary bladder tissues including the suburothelial nerve plexus, interstitial cells of Cajal, and detrusor smooth muscle cells. Diverse stimuli, including those that activate TRP channels expressed by the urothelium, can influence urothelial release of chemical mediators (such as ATP). Changes to the urothelium are associated with a number of bladder pathologies that underlie urinary bladder dysfunction. Urothelial receptor and/or ion channel expression and the release of signalling molecules (such as ATP and nitric oxide) can be altered with bladder disease, neural injury, target organ inflammation, or psychogenic stress. Urothelial receptors and channels represent novel targets for potential therapies that are intended to modulate micturition function or bladder sensation.

Full Text

Duke Authors

Cited Authors

  • Merrill, L; Gonzalez, EJ; Girard, BM; Vizzard, MA

Published Date

  • April 2016

Published In

Volume / Issue

  • 13 / 4

Start / End Page

  • 193 - 204

PubMed ID

  • 26926246

Pubmed Central ID

  • 26926246

Electronic International Standard Serial Number (EISSN)

  • 1759-4820

International Standard Serial Number (ISSN)

  • 1759-4812

Digital Object Identifier (DOI)

  • 10.1038/nrurol.2016.13

Language

  • eng