Oral and extraoral plasmablastic lymphoma: similarities and differences in clinicopathologic characteristics.

Published

Journal Article

Plasmablastic lymphoma (PBL), initially characterized as an aggressive lymphoma arising in the jaw and oral mucosa in HIV-infected patients, was recently reported to occur with extraoral manifestations, heterogeneous histologic findings, and variable association with immunodeficiency states. We reviewed clinical, morphologic, and immunophenotypic features of 13 cases of PBL to determine whether these different subtypes represent distinct morphologic and clinical entities. Two distinct subtypes of PBL were identified and classified as oral and extraoral PBL. The oral PBLs were strongly associated with HIV infection and commonly demonstrated plasmablastic morphologic features without plasmacytic differentiation. Extraoral PBLs tended to occur in patients with underlying non-HIV-related immunosuppression and universally demonstrated plasmacytic differentiation. The patients with oral PBL demonstrated better overall survival compared with patients with extraoral PBL (P = .02). Our findings suggest that PBL with oral and extraoral manifestation represent 2 distinct clinicopathologic entities.

Full Text

Duke Authors

Cited Authors

  • Hansra, D; Montague, N; Stefanovic, A; Akunyili, I; Harzand, A; Natkunam, Y; de la Ossa, M; Byrne, GE; Lossos, IS

Published Date

  • November 2010

Published In

Volume / Issue

  • 134 / 5

Start / End Page

  • 710 - 719

PubMed ID

  • 20959653

Pubmed Central ID

  • 20959653

Electronic International Standard Serial Number (EISSN)

  • 1943-7722

Digital Object Identifier (DOI)

  • 10.1309/AJCPJH6KEUSECQLU

Language

  • eng

Conference Location

  • England