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Pulmonary marginal zone lymphoma: a single centre experience and review of the SEER database.

Publication ,  Journal Article
Stefanovic, A; Morgensztern, D; Fong, T; Lossos, IS
Published in: Leuk Lymphoma
July 2008

Pulmonary marginal zone lymphoma is a rare disease arising from bronchial-associated lymphoid tissue (BALT). There is limited information on clinical presentation, natural history and treatment of this type of lymphoma. We conducted a retrospective review of patients with biopsy-proven BALT lymphoma treated at our institution and patients from the surveillance epidemiology and end results (SEER) database. Twenty-one patients (median age 57) with disease stage IE (n = 10) and IV (n = 11), were treated at our institution. Initial management included observation (n = 4), surgery (n = 5), combination chemotherapy (n = 7), single-agent rituximab (n = 3) and radioimmunotherapy (n = 2). Complete remission was observed in 10, partial remission in 3, stable disease in 7, and disease progression in 1 patient. With a median follow-up of 20 months, Kaplan-Meier estimates for progression-free and overall survival (OS) at 80 months were 90% and 95%, respectively. We identified 326 patients (59% females and 41% males; median age 68 [30 to 85) with BALT lymphoma in the SEER database. Fifty-five per cent had stage IE, 10% stage IIE, 3% stage IIIE, and 22% stage IV disease. After a median follow-up of 35 months, median OS was 112 months, and disease-specific median survival was not reached. At 90 months, disease-specific survival was 85% (CI 77-92) with no significant differences in outcome between patients presenting with different stages. Our single institution experience and review of the SEER database, confirm the indolent features and favourable outcome of this rare disease.

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Published In

Leuk Lymphoma

DOI

EISSN

1029-2403

Publication Date

July 2008

Volume

49

Issue

7

Start / End Page

1311 / 1320

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Retrospective Studies
  • Remission Induction
  • Middle Aged
  • Male
  • Lymphoma, B-Cell, Marginal Zone
  • Lung Neoplasms
  • Immunology
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Stefanovic, A., Morgensztern, D., Fong, T., & Lossos, I. S. (2008). Pulmonary marginal zone lymphoma: a single centre experience and review of the SEER database. Leuk Lymphoma, 49(7), 1311–1320. https://doi.org/10.1080/10428190802064933
Stefanovic, Alexandra, Daniel Morgensztern, Thomas Fong, and Izidore S. Lossos. “Pulmonary marginal zone lymphoma: a single centre experience and review of the SEER database.Leuk Lymphoma 49, no. 7 (July 2008): 1311–20. https://doi.org/10.1080/10428190802064933.
Stefanovic A, Morgensztern D, Fong T, Lossos IS. Pulmonary marginal zone lymphoma: a single centre experience and review of the SEER database. Leuk Lymphoma. 2008 Jul;49(7):1311–20.
Stefanovic, Alexandra, et al. “Pulmonary marginal zone lymphoma: a single centre experience and review of the SEER database.Leuk Lymphoma, vol. 49, no. 7, July 2008, pp. 1311–20. Pubmed, doi:10.1080/10428190802064933.
Stefanovic A, Morgensztern D, Fong T, Lossos IS. Pulmonary marginal zone lymphoma: a single centre experience and review of the SEER database. Leuk Lymphoma. 2008 Jul;49(7):1311–1320.

Published In

Leuk Lymphoma

DOI

EISSN

1029-2403

Publication Date

July 2008

Volume

49

Issue

7

Start / End Page

1311 / 1320

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Retrospective Studies
  • Remission Induction
  • Middle Aged
  • Male
  • Lymphoma, B-Cell, Marginal Zone
  • Lung Neoplasms
  • Immunology
  • Humans