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Role of raltegravir in the management of HIV-1 infection

Publication ,  Journal Article
Okeke, NL; Hicks, C
Published in: HIV/AIDS - Research and Palliative Care
July 15, 2011

The development of multiple agents with potent antiretroviral activity against HIV has ushered in a new age of optimism in the management of patients infected with the virus. However, the viruses’ dynamic ability to develop resistance against these agents necessitates the investigation of novel targets for viral suppression. Raltegravir represents a first-in-class agent targeting the HIV integrase enzyme, which is responsible for integration of virally encoded DNA into the host genome. Over the last 5 years, clinical trials data has demonstrated an increasing role for raltegravir in the management of both treatment-experienced and treatment-naïve HIV-1-infected patients. This review focuses on the evidence supporting raltegravir’s efficacy in an array of clinical settings. Other HIV-1 integrase inhibitors in development are also briefly discussed.

Duke Scholars

Published In

HIV/AIDS - Research and Palliative Care

DOI

EISSN

1179-1373

Publication Date

July 15, 2011

Volume

3

Start / End Page

81 / 92

Related Subject Headings

  • 4206 Public health
  • 4203 Health services and systems
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Okeke, N. L., & Hicks, C. (2011). Role of raltegravir in the management of HIV-1 infection. HIV/AIDS - Research and Palliative Care, 3, 81–92. https://doi.org/10.2147/HIV.S13985
Okeke, N. L., and C. Hicks. “Role of raltegravir in the management of HIV-1 infection.” HIV/AIDS - Research and Palliative Care 3 (July 15, 2011): 81–92. https://doi.org/10.2147/HIV.S13985.
Okeke NL, Hicks C. Role of raltegravir in the management of HIV-1 infection. HIV/AIDS - Research and Palliative Care. 2011 Jul 15;3:81–92.
Okeke, N. L., and C. Hicks. “Role of raltegravir in the management of HIV-1 infection.” HIV/AIDS - Research and Palliative Care, vol. 3, July 2011, pp. 81–92. Scopus, doi:10.2147/HIV.S13985.
Okeke NL, Hicks C. Role of raltegravir in the management of HIV-1 infection. HIV/AIDS - Research and Palliative Care. 2011 Jul 15;3:81–92.

Published In

HIV/AIDS - Research and Palliative Care

DOI

EISSN

1179-1373

Publication Date

July 15, 2011

Volume

3

Start / End Page

81 / 92

Related Subject Headings

  • 4206 Public health
  • 4203 Health services and systems
  • 1103 Clinical Sciences